Antiplatelet therapy has been successful in reducing mortality and morbidity in acute
myocardial infarction. Recent advances in understanding the molecular basis of the role of …

The human cardiovascular system is exposed to plasma 5-hydroxytryptamine (5-HT,
serotonin), usually released from platelets. 5-HT can produce harmful acute and chronic …

Calcitonin gene‐related peptide (CGRP) is a ubiquitous neuropeptide found at the very
centers of the migraine process, both centrally and peripherally. It has been under careful …

Background—The antimigraine drugs ergotamine and sumatriptan may cause angina-like
symptoms, possibly resulting from coronary artery constriction. We compared the coronary …

Identification of the primary products of cyclo‐oxygenase (COX)/prostaglandin synthase (s),
which occurred between 1958 and 1976, was followed by a classification system for …

Synopsis Sumatriptan is a selective agonist at serotonin 5-HT I-like receptors, including 5-
HT 1B/1D subtypes. It is an effective treatment for acute migraine attacks and the injectable …

Background: Migraine is a highly prevalent neurovascular disorder. Objective: Of the many
factors that have been implicated over the years, 5-hydroxytryptamine (5-HT; serotonin) has …

Calcitonin gene-related peptide (CGRP) is a well-studied neuropeptide of relevance for
migraine pathophysiology. Jugular levels of CGRP are increased during migraine attacks …

Background The vascular effects of acute calcitonin gene-related peptide (CGRP) inhibition
are well described, but the effects of sustained inhibition warrant further exploration in …

Endothelins (ETs) are the most potent vasoconstrictors known, and may be the mediators of
the vasoconstrictive phase in migraine attacks. We studied 31 previously selected migraine …