Epigenetic biomarkers: Current strategies and future challenges for their use in the clinical laboratory
JL García-Giménez, M Seco-Cervera… - Critical reviews in …, 2017 - Taylor & Francis
Epigenetic modifications and regulators represent potential molecular elements which
control relevant physiological and pathological features, thereby contributing to the natural …
control relevant physiological and pathological features, thereby contributing to the natural …
“Epigenetic clocks”: Theory and applications in human biology
CP Ryan - American Journal of Human Biology, 2021 - Wiley Online Library
All humans age, but how we age—and how fast—differs considerably from person to
person. This deviation between apparent age and chronological age is often referred to as …
person. This deviation between apparent age and chronological age is often referred to as …
Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts
DNA hypomethylation in certain genes is associated with tobacco exposure but it is
unknown whether these methylation changes translate into increased lung cancer risk. In an …
unknown whether these methylation changes translate into increased lung cancer risk. In an …
Assisted reproductive technologies are associated with limited epigenetic variation at birth that largely resolves by adulthood
B Novakovic, S Lewis, J Halliday, J Kennedy… - Nature …, 2019 - nature.com
More than 7 million individuals have been conceived by Assisted Reproductive
Technologies (ART) and there is clear evidence that ART is associated with a range of …
Technologies (ART) and there is clear evidence that ART is associated with a range of …
DNA methylation changes measured in pre‐diagnostic peripheral blood samples are associated with smoking and lung cancer risk
DNA methylation changes are associated with cigarette smoking. We used the Illumina
Infinium HumanMethylation450 array to determine whether methylation in DNA from pre …
Infinium HumanMethylation450 array to determine whether methylation in DNA from pre …
Inflammation and epigenetic aging are largely independent markers of biological aging and mortality
Limited evidence exists on the link between inflammation and epigenetic aging. We aimed
to (a) assess the cross-sectional and prospective associations of 22 inflammation-related …
to (a) assess the cross-sectional and prospective associations of 22 inflammation-related …
Causal effect of smoking on DNA methylation in peripheral blood: a twin and family study
Background Smoking has been reported to be associated with peripheral blood DNA
methylation, but the causal aspects of the association have rarely been investigated. We …
methylation, but the causal aspects of the association have rarely been investigated. We …
Epigenetic supersimilarity of monozygotic twin pairs
Background Monozygotic twins have long been studied to estimate heritability and explore
epigenetic influences on phenotypic variation. The phenotypic and epigenetic similarities of …
epigenetic influences on phenotypic variation. The phenotypic and epigenetic similarities of …
Analysis of epigenetic changes in survivors of preterm birth reveals the effect of gestational age and evidence for a long term legacy
MN Cruickshank, A Oshlack, C Theda, PG Davis… - Genome medicine, 2013 - Springer
Background Preterm birth confers a high risk of adverse long term health outcomes for
survivors, yet the underlying molecular mechanisms are unclear. We hypothesized that …
survivors, yet the underlying molecular mechanisms are unclear. We hypothesized that …
Novel associations between blood DNA methylation and body mass index in middle-aged and older adults
Results: Cross-sectional analysis identified 310 CpGs associated with BMI with P< 1.0× 10−
7, 225 of which had not been reported previously. Of these 225 novel associations, 172 …
7, 225 of which had not been reported previously. Of these 225 novel associations, 172 …