Image-based screening is used to measure a variety of phenotypes in cells and whole
organisms. Combined with perturbations such as RNA interference, small molecules, and …

Segmentation of the paraxial mesoderm is a major event of vertebrate development that
establishes the metameric patterning of the body axis. This process involves the periodic …

During embryonic development, epithelial cell blocks called somites are periodically formed
according to the segmentation clock, becoming the foundation for the segmental pattern of …

Gastruloids are three-dimensional aggregates of embryonic stem cells that display key
features of mammalian development after implantation, including germ-layer specification …

Sensitive probing of temperature variations on nanometre scales is an outstanding
challenge in many areas of modern science and technology. In particular, a thermometer …

The segmental organization of the vertebral column is established early in embryogenesis,
when pairs of somites are rhythmically produced by the presomitic mesoderm (PSM). The …

Pluripotent stem cells are increasingly used to model different aspects of embryogenesis
and organ formation. Despite recent advances in in vitro induction of major mesodermal …

How signaling dynamics encode information is a central question in biology. During
vertebrate development, dynamic Notch signaling oscillations control segmentation of the …

Individual cellular activities fluctuate but are constantly coordinated at the population level
via cell–cell coupling. A notable example is the somite segmentation clock, in which the …

Segmentation is a fundamental feature of the vertebrate body plan. This metameric
organization is first implemented by somitogenesis in the early embryo, when paired …