Molecular mechanisms of environmental exposures and human disease

H Wu, CM Eckhardt, AA Baccarelli - Nature reviews genetics, 2023 - nature.com
A substantial proportion of disease risk for common complex disorders is attributable to
environmental exposures and pollutants. An appreciation of how environmental pollutants …

Exploring the expanding universe of small RNAs

J Shi, T Zhou, Q Chen - Nature cell biology, 2022 - nature.com
The world of small noncoding RNAs (sncRNAs) is ever-expanding, from small interfering
RNA, microRNA and Piwi-interacting RNA to the recently emerging non-canonical sncRNAs …

METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer

R García-Vílchez, AM Añazco-Guenkova, S Dietmann… - Molecular cancer, 2023 - Springer
Newly growing evidence highlights the essential role that epitranscriptomic marks play in the
development of many cancers; however, little is known about the role and implications of …

A signature of saliva-derived exosomal small RNAs as predicting biomarker for esophageal carcinoma: a multicenter prospective study

K Li, Y Lin, Y Luo, X Xiong, L Wang, K Durante, J Li… - Molecular cancer, 2022 - Springer
Background The tRNA-derived small RNAs (tsRNAs) are produced in a nuclease-
dependent manner in responses to variety of stresses that are common in cancers. We focus …

PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications

J Shi, Y Zhang, D Tan, X Zhang, M Yan, Y Zhang… - Nature cell …, 2021 - nature.com
Although high-throughput RNA sequencing (RNA-seq) has greatly advanced small non-
coding RNA (sncRNA) discovery, the currently widely used complementary DNA library …

Stress granules and processing bodies in translational control

P Ivanov, N Kedersha… - Cold Spring Harbor …, 2019 - cshperspectives.cshlp.org
Stress granules (SGs) and processing bodies (PBs) are non-membrane-enclosed RNA
granules that dynamically sequester translationally inactive messenger ribonucleoprotein …

Noncanonical roles of tRNAs: tRNA fragments and beyond

Z Su, B Wilson, P Kumar, A Dutta - Annual review of genetics, 2020 - annualreviews.org
As one of the most abundant and conserved RNA species, transfer RNAs (tRNAs) are well
known for their role in reading the codons on messenger RNAs and translating them into …

A transfer-RNA-derived small RNA regulates ribosome biogenesis

HK Kim, G Fuchs, S Wang, W Wei, Y Zhang, H Park… - Nature, 2017 - nature.com
Transfer-RNA-derived small RNAs (tsRNAs; also called tRNA-derived fragments) are an
abundant class of small non-coding RNAs whose biological roles are not well understood …

Translational control of stem cell function

JA Saba, K Liakath-Ali, R Green, FM Watt - Nature reviews Molecular …, 2021 - nature.com
Stem cells are characterized by their ability to self-renew and differentiate into many different
cell types. Research has focused primarily on how these processes are regulated at a …

Transfer RNAs as dynamic and critical regulators of cancer progression

AM Pinzaru, SF Tavazoie - Nature Reviews Cancer, 2023 - nature.com
Transfer RNAs (tRNAs) have been historically viewed as non-dynamic adaptors that decode
the genetic code into proteins. Recent work has uncovered dynamic regulatory roles for …