Remdesivir: review of pharmacology, pre‐clinical data, and emerging clinical experience for COVID‐19

SCJ Jorgensen, R Kebriaei… - … : The Journal of Human …, 2020 - Wiley Online Library
The global pandemic of novel coronavirus disease 2019 (COVID‐19) caused by severe
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has created an urgent need for …

Pharmacokinetics of antifungal drugs: practical implications for optimized treatment of patients

R Bellmann, P Smuszkiewicz - Infection, 2017 - Springer
Introduction Because of the high mortality of invasive fungal infections (IFIs), appropriate
exposure to antifungals appears to be crucial for therapeutic efficacy and safety. Materials …

Taskforce report on the diagnosis and clinical management of COVID-19 associated pulmonary aspergillosis

PE Verweij, RJM Brüggemann, E Azoulay… - Intensive care …, 2021 - Springer
Purpose Invasive pulmonary aspergillosis (IPA) is increasingly reported in patients with
severe coronavirus disease 2019 (COVID-19) admitted to the intensive care unit (ICU) …

Remdesivir in patients with acute or chronic kidney disease and COVID-19

ML Adamsick, RG Gandhi, MR Bidell… - Journal of the …, 2020 - journals.lww.com
On May 1, 2020, after review of yet unpublished data from available clinical trials, the US
Food and Drug Administration issued an emergency use authorization (EUA) to permit the …

Cyclodextrins in pharmaceutical formulations I: Structure and physicochemical properties, formation of complexes, and types of complex

SS Jambhekar, P Breen - Drug discovery today, 2016 - Elsevier
Highlights•Cyclodextrins and the complexes they form are described.•Pharmaceutical uses
of cyclodextrin are enumerated.•Physical chemical properties of cyclodextrins are …

Pharmacokinetics and pharmacodynamics of posaconazole

L Chen, EHJ Krekels, PE Verweij, JB Buil, CAJ Knibbe… - Drugs, 2020 - Springer
Posaconazole is typically used for preventing invasive yeast and mold infections such as
invasive aspergillosis in high-risk immunocompromised patients. The oral suspension was …

Recommendation of antimicrobial dosing optimization during continuous renal replacement therapy

L Li, X Li, Y Xia, Y Chu, H Zhong, J Li, P Liang… - Frontiers in …, 2020 - frontiersin.org
Continuous Renal Replacement Therapy (CRRT) is more and more widely used in patients
for various indications recent years. It is still intricate for clinicians to decide a suitable …

Remdesivir use in the setting of severe renal impairment: a theoretical concern or real risk?

NN Pettit, J Pisano, CT Nguyen, AK Lew… - Clinical Infectious …, 2021 - academic.oup.com
Abstract Background Remdesivir (RDV) is US FDA approved for coronavirus disease 2019
(COVID-19) but not recommended in severe renal impairment (SRI, Creatinine clearance< …

Brexanolone (Zulresso): finally, an FDA-approved treatment for postpartum depression

JG Powell, S Garland, K Preston… - Annals of …, 2020 - journals.sagepub.com
Objective: To review the safety and efficacy of brexanolone for the treatment of moderate to
severe postpartum depression (PPD). Data Sources: A literature search through PubMed …

New perspectives on antimicrobial agents: remdesivir treatment for COVID-19

MM Aleissa, EA Silverman… - Antimicrobial agents …, 2020 - Am Soc Microbiol
Remdesivir was recently approved by the Food and Drug Administration for the treatment of
hospitalized patients with coronavirus disease 2019 (COVID-19). Remdesivir is the prodrug …