Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …

Glycosylation is a very common modification of protein and lipid, and most glycosylation
reactions occur in the Golgi. Although the transfer of initial sugar (s) to glycoproteins or …

To take complete advantage of information on within-species polymorphism and divergence
from close relatives, one needs to know the rate and the molecular spectrum of spontaneous …

Glycosylation is an essential post-translational modification that underlies many biological
processes and diseases. α-dystroglycan (α-DG) is a receptor for matrix and synaptic proteins …

α-and β-dystroglycan constitute a membrane-spanning complex that connects the
extracellular matrix to the cytoskeleton. Although a structural role for dystroglycan had been …

The spectrum of all glycan structures—the glycome—is immense. In humans, its size is
orders of magnitude greater than the number of proteins that are encoded by the genome …

Associations between cells and the basement membrane are critical for a variety of
biological events including cell proliferation, cell migration, cell differentiation and the …

Posttranslational modification of alpha-dystroglycan (α-DG) by the like-
acetylglucosaminyltransferase (LARGE) is required for it to function as an extracellular …

The study of the muscle cell in the muscular dystrophies (MDs) has shown that mutant
proteins result in perturbations of many cellular components. MDs have been associated …

Dystrophin is a 427 kDa sub-membrane cytoskeletal protein, associated with the inner
surface membrane and incorporated in a large macromolecular complex of proteins, the …