CXCR3 in T cell function

JR Groom, AD Luster - Experimental cell research, 2011 - Elsevier
CXCR3 is a chemokine receptor that is highly expressed on effector T cells and plays an
important role in T cell trafficking and function. CXCR3 is rapidly induced on naïve cells …

CXCR3 ligands: redundant, collaborative and antagonistic functions

JR Groom, AD Luster - Immunology and cell biology, 2011 - Wiley Online Library
CXCR3 is a chemokine receptor that is rapidly induced on naïve T cells following activation,
and preferentially remains highly expressed on type‐1 helper (Th1)‐type CD4+ T cells …

A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells

G Stary, A Olive, AF Radovic-Moreno, D Gondek… - Science, 2015 - science.org
INTRODUCTION Administering vaccines through nonmucosal routes often leads to poor
protection against mucosal pathogens, presumably because such vaccines do not generate …

CD4+ T cells are necessary and sufficient to confer protection against Chlamydia trachomatis infection in the murine upper genital tract

DC Gondek, AJ Olive, G Stary… - The Journal of …, 2012 - journals.aai.org
Chlamydia trachomatis infection is the most common bacterial sexually transmitted disease
in the United States. Chlamydia infections that ascend to the upper genital tract can persist …

Intravaginal immunization with HPV vectors induces tissue-resident CD8+ T cell responses

N Çuburu, BS Graham, CB Buck… - The Journal of …, 2012 - Am Soc Clin Investig
The induction of persistent intraepithelial CD8+ T cell responses may be key to the
development of vaccines against mucosally transmitted pathogens, particularly for sexually …

The Role of the Immune Response in Chlamydia trachomatis Infection of the Male Genital Tract: A Double-Edged Sword

KA Redgrove, EA McLaughlin - Frontiers in immunology, 2014 - frontiersin.org
Chlamydia trachomatis (CT) is the most prevalent bacterial sexually transmitted infection in
the world, with more than 100 million cases reported annually. While there have been …

Genital Chlamydia trachomatis: understanding the roles of innate and adaptive immunity in vaccine research

S Vasilevsky, G Greub… - Clinical microbiology …, 2014 - Am Soc Microbiol
Chlamydia trachomatis is the leading cause of bacterial sexually transmitted disease
worldwide, and despite significant advances in chlamydial research, a prophylactic vaccine …

The cell-surface 5′-nucleotidase CD73 defines a functional T memory cell subset that declines with age

F Fang, W Cao, W Zhu, N Lam, L Li, S Gaddam… - Cell reports, 2021 - cell.com
Memory T cells exhibit considerable diversity that determines their ability to be protective.
Here, we examine whether changes in T cell heterogeneity contribute to the age-associated …

Genetic Variation in Chlamydia Trachomatis and Their Hosts: Impact on Disease Severity and Tissue Tropism

H Abdelsamed, J Peters, GI Byrne - Future microbiology, 2013 - Taylor & Francis
Chlamydia trachomatis infections are a global health problem. This obligate intracellular
bacterial pathogen comprises lymphogranuloma venereum (L1–L3), ocular (A–C) and …

Immunopathogenesis of genital Chlamydia infection: insights from mouse models

J Dockterman, J Coers - Pathogens and Disease, 2021 - academic.oup.com
Chlamydiae are pathogenic intracellular bacteria that cause a wide variety of diseases
throughout the globe, affecting the eye, lung, coronary arteries and female genital tract …