Epidemiology and burden of human papillomavirus and related diseases, molecular pathogenesis, and vaccine evaluation

AJ Kombe Kombe, B Li, A Zahid, HM Mengist… - Frontiers in public …, 2021 - frontiersin.org
Diagnosed in more than 90% of cervical cancers, the fourth deadliest cancer in women,
human papillomavirus (HPV) is currently the most common pathogen responsible for female …

The microbiome and gynaecological cancer development, prevention and therapy

P Łaniewski, ZE Ilhan, MM Herbst-Kralovetz - Nature Reviews Urology, 2020 - nature.com
The female reproductive tract (FRT), similar to other mucosal sites, harbours a site-specific
microbiome, which has an essential role in maintaining health and homeostasis. In the …

Risk factors for human papillomavirus infection, cervical intraepithelial neoplasia and cervical cancer: an umbrella review and follow-up Mendelian randomisation …

SJ Bowden, T Doulgeraki, E Bouras, G Markozannes… - BMC medicine, 2023 - Springer
Background Persistent infection by oncogenic human papillomavirus (HPV) is necessary
although not sufficient for development of cervical cancer. Behavioural, environmental, or …

HPV infection alters vaginal microbiome through down-regulating host mucosal innate peptides used by Lactobacilli as amino acid sources

A Lebeau, D Bruyere, P Roncarati, P Peixoto… - Nature …, 2022 - nature.com
Despite the high prevalence of both cervico-vaginal human papillomavirus (HPV) infection
and bacterial vaginosis (BV) worldwide, their causal relationship remains unclear. While BV …

Cervical intraepithelial neoplasia disease progression is associated with increased vaginal microbiome diversity

A Mitra, DA MacIntyre, YS Lee, A Smith, JR Marchesi… - Scientific reports, 2015 - nature.com
Persistent infection with oncogenic Human Papillomavirus (HPV) is necessary for cervical
carcinogenesis. Although evidence suggests that the vaginal microbiome plays a functional …

The vaginal microbiota, human papillomavirus infection and cervical intraepithelial neoplasia: what do we know and where are we going next?

A Mitra, DA MacIntyre, JR Marchesi, YS Lee… - Microbiome, 2016 - Springer
The vaginal microbiota plays a significant role in health and disease of the female
reproductive tract. Next-generation sequencing techniques based upon the analysis of …

Vaginal microbiome and cervical cancer

M Kyrgiou, AB Moscicki - Seminars in Cancer Biology, 2022 - Elsevier
The female reproductive tract, similar to other mucosal sites, harbors a specific microbiome
commonly dominated by Lactobacillus species (spp.), which has an essential role in …

Vaginal dysbiosis and the risk of human papillomavirus and cervical cancer: systematic review and meta-analysis

N Brusselaers, S Shrestha, J Van De Wijgert… - American journal of …, 2019 - Elsevier
Objective The vaginal microbiota proposedly influence the association between human
papillomavirus and cervical cancer. Our aim was to assess whether vaginal dysbiosis affects …

Lactobacillus species as biomarkers and agents that can promote various aspects of vaginal health

MI Petrova, E Lievens, S Malik, N Imholz… - Frontiers in …, 2015 - frontiersin.org
The human body is colonized by a vast number of microorganisms collectively referred to as
the human microbiota. One of the main microbiota body sites is the female genital tract …

Cervical microbiome and cytokine profile at various stages of cervical cancer: a pilot study

A Audirac-Chalifour, K Torres-Poveda… - PloS one, 2016 - journals.plos.org
Cervical cancer (CC) is caused by high-risk human papillomavirus persistence due to the
immunosuppressive tumor microenvironment mediated by cytokines. Vaginal microbiota …