Natural products from Chinese medicines with potential benefits to bone health

CT Che, MS Wong, CWK Lam - Molecules, 2016 - mdpi.com
Osteoporosis is a progressive, systemic bone disorder characterized by loss of bone mass
and microstructure, leading to reduced bone strength and increased risk of fracture. It is …

Pharmacological activities of ginsenoside Rg5

MY Liu, F Liu, YL Gao, JN Yin… - Experimental and …, 2021 - spandidos-publications.com
Ginseng, a perennial plant belonging to genus Panax, has been widely used in traditional
herbal medicine in East Asia and North America. Ginsenosides are the most important …

Anticancer activity of silver nanoparticles from Panax ginseng fresh leaves in human cancer cells

V Castro-Aceituno, S Ahn, SY Simu, P Singh… - Biomedicine & …, 2016 - Elsevier
The pharmaceutical role of silver nanoparticles has been increased over the last decades,
especially those synthesized through herbal medicinal plants, due to their variety of …

Ginsenoside Rg5: Rk1 attenuates TNF-α/IFN-γ-induced production of thymus-and activation-regulated chemokine (TARC/CCL17) and LPS-induced NO production via …

S Ahn, MH Siddiqi, VC Aceituno, SY Simu… - In Vitro Cellular & …, 2016 - Springer
Atopic dermatitis (AD) is a chronic skin disease that affects millions of people worldwide.
Keratinocytes and macrophages are two cells types that play a pivotal role in the …

Emerging natural-product-based treatments for the management of osteoarthritis

ML Pérez-Lozano, A Cesaro, M Mazor, E Esteve… - Antioxidants, 2021 - mdpi.com
Osteoarthritis (OA) is a complex degenerative disease in which joint homeostasis is
disrupted, leading to synovial inflammation, cartilage degradation, subchondral bone …

Anti-Inflammatory Effect of Ginsenoside Rh2-Mix on Lipopolysaccharide-Stimulated RAW 264.7 Murine Macrophage Cells

D Baatar, MZ Siddiqi, WT Im, N Ul Khaliq… - Journal of Medicinal …, 2018 - liebertpub.com
Ginsenoside Rh2, a protopanaxadiol saponin from ginseng, has been reported to have
strong anti-inflammatory activity. However, the concentration of ginsenoside Rh2 is very low …

Effects of ginsenosides on bone remodelling for novel drug applications: a review

N Yang, D Liu, X Zhang, J Li, M Wang, T Xu, Z Liu - Chinese Medicine, 2020 - Springer
Background Ginsenosides are pharmacologically active compounds that are often extracted
from the Panax plant for their medicinal properties. Ginsenosides have multiple effects …

Ginsenoside Re promotes osteoblast differentiation in mouse osteoblast precursor MC3T3-E1 cells and a Zebrafish model

HM Kim, DH Kim, HJ Han, CM Park, SR Ganipisetti… - Molecules, 2016 - mdpi.com
Bone homeostasis is tightly regulated to balance bone formation and bone resorption. Many
anabolic drugs are used as bone-targeted therapeutic agents for the promotion of osteoblast …

Inhibition of Osteoclast Differentiation by Ginsenoside Rg3 in RAW264.7 Cells via RANKL, JNK and p38 MAPK Pathways Through a Modulation of Cathepsin K: An In Silico and …

MH Siddiqi, MZ Siddiqi, S Kang, HY Noh… - Phytotherapy …, 2015 - Wiley Online Library
Various studies have demonstrated that overexpression of cathepsin K (Cat‐K) causes
excessive bone loss, which ultimately leads to a variety of bone diseases including …

[HTML][HTML] Enhanced production of ginsenoside Rh2 (S) from PPD-type major ginsenosides using BglSk cloned from Saccharibacillus kuerlensis together with two …

MZ Siddiqi, HA Ximenes, BK Song, HY Park… - Saudi Journal of …, 2021 - Elsevier
Abstract Background Ginsenoside Rh2 (S) is a promising compound for the prevention of
various kinds of cancers, inflammation, and diabetes. However, due to its low concentration …