Treatment of active pulmonary tuberculosis in adults: current standards and recent advances: insights from the Society of Infectious Diseases Pharmacists

RG Hall, RD Leff, T Gumbo - Pharmacotherapy: The Journal of …, 2009 - Wiley Online Library
Tuberculosis is a global pandemic, with 9 million new cases of the disease and
approximately 2 million deaths each year. More than 98% of patients treated for tuberculosis …

Influence of Spirulina platensis and ascorbic acid on amikacin-induced nephrotoxicity in rabbits

MM Abdel-Daim, A Ahmed, H Ijaz, AI Abushouk… - … science and pollution …, 2019 - Springer
The current study was performed to investigate the nephroprotective efficacy of Spirulina
platensis (SP) and the possible benefits of combining SP and ascorbic acid (AA) in …

The nephroprotective properties of taurine-amikacin treatment in rats are mediated through HSP25 and TLR-4 regulation

N Madbouly, A Azmy, A Salama, A El-Amir - The Journal of Antibiotics, 2021 - nature.com
Amikacin (AMK) is one of the most effective aminoglycoside antibiotics. However,
nephrotoxicity is a major deleterious and dose-limiting side effect associated with its clinical …

Thymoquinone ameliorates amikacin induced oxidative damage in rat brain tissue

S Bilgiç, M Özgöçmen, MK Ozer - Biotechnic & Histochemistry, 2023 - Taylor & Francis
We investigated the potential neuroprotective effects of thymoquinone (TQ) on amikacin (AK)
induced oxidative damage in rat brain. We used 21 male rats divided randomly into three …

Pretreatment with Pentoxifylline and N-Acetylcysteine in Liver Ischemia Reperfusion-Induced Renal Injury

B Seifi, M Kadkhodaee, F Delavari, S Mikaeili… - Renal …, 2012 - Taylor & Francis
Background and Aims: Acute hepatic injury causes systematic inflammatory responses
which may finally lead to functional disturbances in remote organs. In this study, the effects …

Prevention of nephrotoxicity induced by amikacin: The role of misoprostol, A prostaglandin E1 analogue

S Azırak - Prostaglandins & Other Lipid Mediators, 2023 - Elsevier
Amikacin (AK) is an aminoglycoside that is widely used to treat life-threatening Gram-
negative infections, especially in intensive care units. Despite its wide clinical indications …

Effects of pentoxifylline on amikacin-induced nephrotoxicity in rats

MK Ozer, H Asci, M Oncu, S Yesilot, M Savran… - Renal failure, 2009 - Taylor & Francis
The nephrotoxicity of amikacin (AK) was prevented with pentoxifylline (PTX) in a rat model.
Rats were received a single injection of AK (1.2 g/kg, ip) with or without PTX pretreatment …

[PDF][PDF] The protective effect of Omega3 against amikacin-induced nephrotoxicity in rats

AT Hlail, HR Faraj, WS Abdulredha - Systematic reviews in pharmacy, 2020 - portal.arid.my
Renal system is vital for total body homeostasis because the kidney plays a principle role in
the excretion of metabolic waste products and in the regulation of extracellular fluid volume …

Prediction of tissue exposures of polymyxin-B, amikacin and sulbactam using physiologically-based pharmacokinetic modeling

M Wu, K Feng, X Wu, C Liu, S Zhu, FS Martins… - Frontiers in …, 2024 - frontiersin.org
Background The combination antimicrobial therapy consisting of amikacin, polymyxin-B, and
sulbactam demonstrated in vitro synergy against multi-drug resistant Acinetobacter …

Evaluation of the possible nephroprotective effects of vitamin E and rosuvastatin in amikacin‐induced renal injury in rats

A Selim, MM Khalaf, AM Gad… - Journal of Biochemical …, 2017 - Wiley Online Library
Amikacin (AMIK) is an aminoglycoside antibiotic that possesses considerable nephrotoxic
adverse effects. This study examined the protective effects of vitamin E (VIT. E) or …