The seminal hypotheses proposed over the years for enzymatic catalysis are scrutinized.
The historical record is explored from both biochemical and theoretical perspectives …

Recent advances in high-throughput methods have provided us with a first glimpse of the
overall structure of molecular interaction networks in biological systems. Ultimately, we …

Most proteins have been formed by gene duplication, recombination, and divergence.
Proteins of known structure can be matched to about 50% of genome sequences, and these …

Numerous studies have considered the emergence of metabolic pathways, but the modes of
recent evolution of metabolic networks are poorly understood. Here, we integrate …

▪ Abstract We can now assign about two thirds of the sequences from completed genomes to
as few as 1400 domain families for which structures are known and thus more ancient …

Despite only becoming popular at the beginning of this decade, biomolecular networks are
now frameworks that facilitate many discoveries in molecular biology. The nodes of these …

Winner, 2009 Victorian Premier's Literary Prize for Science Writing Among the major events
in evolutionary history, few rival in importance the appearance of animals. The Rise of …

Gene duplication is postulated to have played a major role in the evolution of biological
novelty. Here, gene duplication is examined across levels of biological organization in an …

One fundamental goal of current research is to understand how complex biomolecular
networks took the form that we observe today. Cellular metabolism is probably one of the …

The evolution of enzymes and pathways is under debate. Recent studies show that
recruitment of single enzymes from different pathways could be the driving force for pathway …