Actionable mechanisms of drug tolerance and resistance in Mycobacterium tuberculosis

D Datta, S Jamwal, N Jyoti, S Patnaik… - The FEBS …, 2024 - Wiley Online Library
The emergence of antimicrobial resistance (AMR) across bacterial pathogens presents a
serious threat to global health. This threat is further exacerbated in tuberculosis (TB), mainly …

Structure and function of Mycobacterium tuberculosis EfpA as a lipid transporter and its inhibition by BRD-8000.3

D Li, X Zhang, Y Yao, X Sun, J Sun, X Ma… - Proceedings of the …, 2024 - pnas.org
EfpA, the first major facilitator superfamily (MFS) protein identified in Mycobacterium
tuberculosis (Mtb), is an essential efflux pump implicated in resistance to multiple drugs …

The mycobacterial glycoside hydrolase LamH enables capsular arabinomannan release and stimulates growth

A Franklin, VC Salgueiro, AJ Layton, R Sullivan… - nature …, 2024 - nature.com
Mycobacterial glycolipids are important cell envelope structures that drive host-pathogen
interactions. Arguably, the most important are lipoarabinomannan (LAM) and its precursor …

Mutational analysis in Corynebacterium stationis MFS transporters for improving nucleotide bioproduction

K Kinose, K Shinoda, T Konishi, H Kawasaki - Applied Microbiology and …, 2024 - Springer
Product secretion from an engineered cell can be advantageous for microbial cell factories.
Extensive work on nucleotide manufacturing, one of the most successful microbial …

Efflux pumps and membrane permeability contribute to intrinsic antibiotic resistance in Mycobacterium abscessus

K McGowen, T Funck, X Wang, S Zinga, ID Wolf… - …, 2024 - pmc.ncbi.nlm.nih.gov
Mycobacterium abscessus is a pulmonary pathogen that exhibits intrinsic resistance to
antibiotics, but the factors driving this resistance are incompletely understood. Insufficient …

From ancestor to pathogen: Expansion and evolutionary adaptations of multidrug resistance causing MFS efflux pumps in mycobacteria

G Singh, Y Akhter - Gene, 2025 - Elsevier
Multidrug resistance (MDR) in Mycobacterium tuberculosis (Mtb) is a growing threat. Efflux
pumps, particularly those belonging to the Major Facilitator Superfamily (MFS), play a key …

One-step drug transport across two membranes of Gram-negative bacteria

B Luisi, Z Zhong, T Maimaiti, X Gao, R Dong… - 2024 - researchsquare.com
Transport of proteins and small molecules across the complex cell envelope of Gram-
negative bacteria is crucial for their survival and interaction with their environment and is …

Selection of new therapeutic targets in relation to lipid metabolism in Mycobacterium abscessus

T Dargham - 2024 - hal.science
Lipid droplets are conserved organelles in a large number of organisms, playing an
essential role in energy storage and membrane renewal. Among prokaryotes …