MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
R Rupaimoole, FJ Slack - Nature reviews Drug discovery, 2017 - nature.com
In just over two decades since the discovery of the first microRNA (miRNA), the field of
miRNA biology has expanded considerably. Insights into the roles of miRNAs in …
miRNA biology has expanded considerably. Insights into the roles of miRNAs in …
Tumor suppressor miRNA in cancer cells and the tumor microenvironment: mechanism of deregulation and clinical implications
K Otmani, P Lewalle - Frontiers in oncology, 2021 - frontiersin.org
MicroRNAs (miRNAs) are noncoding RNAs that have been identified as important
posttranscriptional regulators of gene expression. miRNAs production is controlled at …
posttranscriptional regulators of gene expression. miRNAs production is controlled at …
[HTML][HTML] Role of miR-2392 in driving SARS-CoV-2 infection
MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene
regulation that have a major impact on many diseases and provide an exciting avenue …
regulation that have a major impact on many diseases and provide an exciting avenue …
microRNA-122 amplifies hepatitis C virus translation by shaping the structure of the internal ribosomal entry site
Abstract The liver-specific microRNA-122 (miR-122) recognizes two conserved sites at the
5′ end of the hepatitis C virus (HCV) genome and contributes to stability, translation, and …
5′ end of the hepatitis C virus (HCV) genome and contributes to stability, translation, and …
The role of the liver-specific microRNA, miRNA-122 in the HCV replication cycle
RD Kunden, JQ Khan, S Ghezelbash… - International Journal of …, 2020 - mdpi.com
Hepatitis C virus (HCV) replication requires annealing of a liver specific microRNA, miR-122
to 2 sites on 5′ untranslated region (UTR). While, microRNAs downregulate gene …
to 2 sites on 5′ untranslated region (UTR). While, microRNAs downregulate gene …
MicroRNA 122 affects both the initiation and the maintenance of hepatitis C virus infections
M Panigrahi, PA Thibault, JA Wilson - Journal of Virology, 2022 - Am Soc Microbiol
ABSTRACT A liver-specific microRNA, miR-122, anneals to the hepatitis C virus (HCV)
genomic 5′ terminus and is essential for virus replication in cell culture. However …
genomic 5′ terminus and is essential for virus replication in cell culture. However …
The emerging role and significance of circular RNAs in viral infections and antiviral immune responses: possible implication as theranostic agents
Circular RNAs (circRNAs) are ubiquitously expressed, covalently closed rings, produced by
pre-mRNA splicing in a reversed order during post-transcriptional processing. Circularity …
pre-mRNA splicing in a reversed order during post-transcriptional processing. Circularity …
Using genome sequence to enable the design of medicines and chemical probes
AJ Angelbello, JL Chen, JL Childs-Disney… - Chemical …, 2018 - ACS Publications
Rapid progress in genome sequencing technology has put us firmly into a postgenomic era.
A key challenge in biomedical research is harnessing genome sequence to fulfill the …
A key challenge in biomedical research is harnessing genome sequence to fulfill the …
Hepatitis C virus translation regulation
M Niepmann, GK Gerresheim - International journal of molecular sciences, 2020 - mdpi.com
Translation of the hepatitis C virus (HCV) RNA genome is regulated by the internal ribosome
entry site (IRES), located in the 5'-untranslated region (5′ UTR) and part of the core protein …
entry site (IRES), located in the 5'-untranslated region (5′ UTR) and part of the core protein …
miR-122 and Ago interactions with the HCV genome alter the structure of the viral 5′ terminus
Hepatitis C virus (HCV) is a positive-sense RNA virus that interacts with the liver-specific
microRNA, miR-122. miR-122 binds to two sites in the 5′ untranslated region (UTR) and …
microRNA, miR-122. miR-122 binds to two sites in the 5′ untranslated region (UTR) and …