Gut hormones orchestrate pivotal physiological processes in multiple metabolically active
tissues, including the pancreas, liver, adipose tissue, gut and central nervous system …

Parietal cells are responsible for gastric acid secretion, which aids in the digestion of food,
absorption of minerals, and control of harmful bacteria. However, a fine balance of activators …

During the past decade, proof of the principle that peptide receptors can be used
successfully for in vivo targeting of human cancers has been provided. The molecular basis …

Cholecystokinin (CCK) was discovered in 1928 in jejunal extracts as a gallbladder
contraction factor. It was later shown to be member of a peptide family, which are all ligands …

Cholecystokinin and gastrin receptors (CCK1R and CCK2R) are G protein-coupled
receptors that have been the subject of intensive research in the last 10 years with …

Cholecystokinin (CCK) has emerged as an important mammalian neuropeptide, localized in
peripheral organs and in the central nervous system. This review presents an overview of …

Peptides, as neurotransmitters, neuromodulators, and hormones, influence a multitude of
physiological processes by signal transduction mediated through receptors. In addition …

One of the hallmarks of the mammalian stomach is its ability to secrete large quantities of
concentrated (0.16 mol/L) hydrochloric acid (HCl). 1 Although it is generally assumed that …

Abstract Cholecystokinin (CCK)-A and CCK-B/gastrin receptors were evaluated with in vitro
receptor autoradiography in 406 human tumors of various origins using a sulfated 125I …

Rehfeld, Jens F. The New Biology of Gastrointestinal Hormones. Physiol. Rev. 78: 1087–
1108, 1998.—The classic concept of gastrointestinal endocrinology is that of a few peptides …