Parvovirus diversity and DNA damage responses

SF Cotmore, P Tattersall - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
Parvoviruses have a linear single-stranded DNA genome, around 5 kb in length, with short
imperfect terminal palindromes that fold back on themselves to form duplex hairpin …

Nuclear entry and egress of parvoviruses

S Mattola, V Aho… - Molecular …, 2022 - Wiley Online Library
Parvoviruses are small non‐enveloped single‐stranded DNA viruses, which depend on host
cell nuclear transcriptional and replication machinery. After endosomal exposure of nuclear …

Protein diffusion in mammalian cell cytoplasm

T Kühn, TO Ihalainen, J Hyväluoma, N Dross… - PloS one, 2011 - journals.plos.org
We introduce a new method for mesoscopic modeling of protein diffusion in an entire cell.
This method is based on the construction of a three-dimensional digital model cell from …

[HTML][HTML] Importin α/β-dependent nuclear transport of human parvovirus B19 nonstructural protein 1 is essential for viral replication

G Alvisi, E Manaresi, EM Cross, M Hoad, N Akbari… - Antiviral Research, 2023 - Elsevier
Abstract Human parvovirus B19 (B19V) is a major human pathogen causing a variety of
diseases, characterized by a selective tropism to human progenitor cells in bone marrow. In …

Analysis of cis and trans Requirements for DNA Replication at the Right-End Hairpin of the Human Bocavirus 1 Genome

W Shen, X Deng, W Zou, JF Engelhardt, Z Yan… - Journal of …, 2016 - Am Soc Microbiol
Parvoviruses are single-stranded DNA viruses that use the palindromic structures at the
ends of the viral genome for their replication. The mechanism of parvovirus replication has …

Canine parvovirus NS1 induces host translation shutoff by reducing mTOR phosphorylation

X Wang, X Hao, Y Zhao, X Xiao, S Li, P Zhou - Journal of Virology, 2024 - journals.asm.org
ABSTRACT Canine parvovirus type 2 (CPV-2) is a member of the Parvoviridae family,
characterized by its small, non-enveloped virions containing a linear single-stranded DNA …

Molecular Characterization and Evolutionary Analyses of Carnivore Protoparvovirus 1 NS1 Gene

F Mira, M Canuti, G Purpari, V Cannella, S Di Bella… - Viruses, 2019 - mdpi.com
Carnivore protoparvovirus 1 is the etiological agent of a severe disease of terrestrial
carnivores. This unique specie encompasses canine parvovirus type 2 (CPV-2) and feline …

Vesicular egress of non-enveloped lytic parvoviruses depends on gelsolin functioning

S Bär, L Daeffler, J Rommelaere, JPF Nüesch - PLoS pathogens, 2008 - journals.plos.org
The autonomous parvovirus Minute Virus of Mice (MVM) induces specific changes in the
cytoskeleton filaments of infected permissive cells, causing in particular the degradation of …

[HTML][HTML] Recruitment of DNA replication and damage response proteins to viral replication centers during infection with NS2 mutants of Minute Virus of Mice (MVM)

Z Ruiz, IS Mihaylov, SF Cotmore, P Tattersall - Virology, 2011 - Elsevier
MVM NS2 is essential for viral DNA amplification, but its mechanism of action is unknown. A
classification scheme for autonomous parvovirus-associated replication (APAR) center …

Nucleocytoplasmic shuttling of porcine parvovirus NS1 protein mediated by the CRM1 nuclear export pathway and the importin α/β nuclear import pathway

L Cao, F Fu, J Chen, H Shi, X Zhang, J Liu… - Journal of …, 2022 - Am Soc Microbiol
ABSTRACT Porcine parvovirus (PPV) NS1, the major nonstructural protein of this virus,
plays an important role in PPV replication. We show, for the first time, that NS1 dynamically …