The P2X7 receptor (P2X7R), an ATP-gated ion channel, has emerged as a crucial player in
neuroinflammation and a promising therapeutic target for neurodegenerative disorders. This …

The central nervous system, information integration center of the body, is mainly composed
of neurons and glial cells. The neuron is one of the most basic and important structural and …

Neuroinflammation is highly influenced by microglia, particularly through activation of the
NLRP3 inflammasome and subsequent release of IL-1β. Extracellular ATP is a strong …

Elevated Expression of Two Pore Potassium Channel THIK-1 in Alzheimer’s Disease: An
Inflammatory Mechanism - IOS Press You are viewing a javascript disabled version of the site …

The central nervous system (CNS) relies on precise regulation of potassium ion (K+)
concentrations to maintain physiology. This regulation involves complex cellular and …

The NLRP3 inflammasome is a multiprotein complex that plays a vital role in regulating
inflammatory signaling and the innate immune system. Activation of NLRP3 by accumulation …

TWIK2 channel plays a critical role in NLRP3 inflammasome activation and mice deficient in
TWIK2 channel are protected from sepsis and inflammatory lung injury. However, inhibitors …

P2X receptors are a family of seven ATP-gated ion channels that trigger physiological and
pathophysiological responses in a variety of cells. Five of the family members are sensitive …

The aim of this study was to examine the effects of ML365, a two-pore potassium channel
(K2P) inhibitor, on postoperative cognitive impairment (POCD). A mouse model of POCD …

The halothane-inhibited K2P leak potassium channel K2P13. 1 (THIK-1) 1–3 is found in
diverse cells1, 4 including neurons1, 5 and microglia6–8 where it affects surveillance6 …