Tuberculosis (TB) is a serious global public health challenge that results in significant
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …

Mycobacterium tuberculosis is a leading cause of mortality worldwide and establishes a
long-lived latent infection in a substantial proportion of the human population. Multiple lines …

Immunopolymorphism is considered as an important aspect behind the resistance or
susceptibility of the host to an infectious disease. Over the years, researchers have explored …

Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a major health problem,
with 10 million new cases diagnosed each year. Innate immunity plays an important role in …

There has been growing debate over the nature of the genetic contribution to individual
susceptibility to common complex diseases such as diabetes, osteoporosis, and cancer. The …

Pathogens have always been a major cause of human mortality, so they impose strong
selective pressure on the human genome. Data from population genetic studies, including …

Pathogenic mutations in APP, PSEN1, PSEN2, MAPT and GRN have previously been linked
to familial early onset forms of dementia. Mutation screening in these genes has been …

Tuberculosis (TB) is a leading cause worldwide of human mortality attributable to a single
infectious agent. Recent studies targeting candidate genes and “case-control” association …

The limitations of genome-wide association (GWA) studies that focus on the phenotypic
influence of common genetic variants have motivated human geneticists to consider the …

Infectious diseases have been paramount among the threats to health and survival
throughout human evolutionary history. Natural selection is therefore expected to act …