Since the original somatomedin hypothesis was conceived, a number of important
discoveries have allowed investigators to modify the concept. Originally somatic growth was …

Introduction H YPOPHYSECTOMIZED rats have a defect in the synthesis of matrix protein
which is rapidly repaired by the administration of GH in vivo. In 1957, it was first reported that …

Insulin‐like growth factors (IGFs) are essential for growth and survival that suppress
apoptosis and promote cell cycle progression, angiogenesis, and metastatic activities in …

IGF-I is expressed in virtually every tissue of the body, but with much higher expression in
the liver than in any other tissue. Studies using mice with liver-specific IGF-I knockout have …

To ascertain if IGF-1 is a regulator of local muscle growth, total RNA was extracted from
rabbit muscle induced to undergo rapid hypertrophy using active stretch and from control …

The discovery that IGF-I mRNAs encoding isoforms of the pro-IGF-I molecule are
differentially regulated in response to mechanical stress in skeletal muscle has been the …

In several species, including humans, circulating insulin-like growth factor I (IGF-I) levels
increase during the onset of puberty, suggesting that this peptide contributes to attaining …

GH insensitivity (GHI) presents in childhood as growth failure and in its severe form is
associated with dysmorphic and metabolic abnormalities. GHI may be caused by genetic …

Insulin-like growth factor 1 (IGF-1) is induced after hypoxic–ischemic (HI) brain injury, and
therapeutic studies suggest that IGF-1 may restrict delayed neuronal and glial cell loss. We …

Insulin and the insulin-like growth factors (I and II) are homologous peptides essential to
normal metabolism as well as growth. These peptide hormones are present in the brain …