Cellular senescence plays a critical role in tumorigenesis. Once thought of as a tissue
culture artefact by some researchers, senescence is now a major field of study. Although …

The JAK/STAT3 signaling pathway plays an essential role in various types of cancers.
Activation of this pathway leads to increased tumorigenic and metastatic ability, the transition …

Emerging evidence indicates that various cancers can gain resistance to targeted therapies
by acquiring lineage plasticity. Although various genomic and transcriptomic aberrations …

The success of next-generation androgen receptor (AR) pathway inhibitors, such as
abiraterone acetate and enzalutamide, in treating prostate cancer has been hampered by …

Interleukin-6 (IL-6) is a multifunctional cytokine which plays an important role in a wide
range of biologic activities in different types of cell including tumor cells. IL-6 is involved in …

Environmental and genetic aspects are reflected in the development of prostate cancer. In
this context, there is growing evidence that chronic inflammation is involved in the regulation …

Abstract Epithelial-mesenchymal transition (EMT), a key step in the early stages of cancer
metastasis, is orchestrated by several signaling pathways, including IL-6/JAK/STAT3 and …

Abstract Interleukin-6 (IL-6) is a cytokine present in tumor microenvironment. Elevated level
of IL-6 is associated with cancer cell proliferation, angiogenesis and metastasis through …

Epithelial–mesenchymal plasticity (EMP) plays critical roles during embryonic development,
wound repair, fibrosis, inflammation and cancer. During cancer progression, EMP results in …

The epithelial-mesenchymal transition (EMT) is a process through which epithelial cells
trans-differentiate and acquire an aggressive mesenchymal phenotype. In tumor cells, EMT …