Yersinia pestis, the bacterial causative agent of plague, remains an important threat to
human health. Plague is a rodent-borne disease that has historically shown an outstanding …

Epidemiological studies point to race as a determining factor in cancer susceptibility. In US
registries recording cancer incidence and survival by race (distinguishing 'black versus …

Pathogens and the diseases they cause have been among the most important selective
forces experienced by humans during their evolutionary history. Although adaptive alleles …

Human genes governing innate immunity provide a valuable tool for the study of the
selective pressure imposed by microorganisms on host genomes. A comprehensive …

Adaptation to a wide range of pathogenic environments is a major aspect of the ecological
adaptations of vertebrates during evolution. Toll-like receptors (TLRs) are ancient …

Toll-like receptors (TLRs) play a crucial role in innate immunity and provide a first line of host
defense against invading pathogens. Of the identified human TLRs, TLR10 remains an …

Humans are complex social beings. To understand human behaviour, an integrated
perspective is required-one which considers both what we regularly do (our personality …

Human populations have been shaped by catastrophes that may have left long-lasting
signatures in their genomes. One notable example is the second plague pandemic that …

The evolution of mankind has constantly been influenced by the pathogens encountered.
The various populations of modern humans that ventured out of Africa adapted to different …

The wealth of available genetic information is allowing the reconstruction of human
demographic and adaptive history. Demography and purifying selection affect the purge of …