A growing body of evidence suggests that mechanical signals emanating from the cell's
microenvironment are fundamental regulators of cell behaviour. Moreover, at the …

YAP and TAZ are highly related transcriptional regulators pervasively activated in human
malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer …

Whether cell forces or extracellular matrix (ECM) can impact genome integrity is largely
unclear. Here, acute perturbations (∼ 1 h) to actomyosin stress or ECM elasticity cause …

Repeated rounds of nuclear envelope (NE) rupture and repair have been observed in
laminopathy and cancer cells and result in intermittent loss of nucleus compartmentalization …

Cell motility is essential for life and development. Unfortunately, cell migration is also linked
to several pathological processes, such as cancer metastasis. Cells' ability to migrate relies …

The actin depolymerizing factor (ADF)/cofilin family comprises small actin-binding proteins
with crucial roles in development, tissue homeostasis and disease. They are best known for …

Highlights•YAP/TAZ are activated in a broad number of solid tumors.•YAP/TAZ instrumental
for tumor initiation, growth, metastasis and chemoresistance.•Several inputs control …

Long-range signaling by morphogens and their inhibitors define embryonic patterning yet
quantitative data and models are rare, especially in humans. Here, we use a human …

Mutations in the lamin A/C gene (LMNA) cause dilated cardiomyopathy associated with
increased activity of ERK1/2 in the heart. We recently showed that ERK1/2 phosphorylates …

Neuronal polarization establishes distinct molecular structures to generate a single axon
and multiple dendrites. Studies over the past years indicate that this efficient separation is …