COVID-19 poses an extraordinary threat to global public health and an effective vaccine
could provide a key means of overcoming this crisis. Human challenge studies involve the …

Zika virus outbreaks have been explosive and unpredictable and have led to significant
adverse health effects—as well as considerable public anxiety. Significant scientific work …

Controlled human challenge trials of SARS-CoV-2 vaccine candidates could accelerate the
testing and potential rollout of efficacious vaccines. By replacing conventional phase 3 …

The recent epidemic of Zika virus (ZIKV) in the Americas has revealed the devastating
consequences of ZIKV infection, particularly in pregnant women. Congenital Zika syndrome …

This report of the WHO Working Group for Guidance on Human Challenge Studies in COVID-
19 outlines ethical standards for COVID-19 challenge studies. It includes eight Key Criteria …

The pandemic of coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, poses an
extraordinary threat to global public health, socioeconomic stability, food security and other …

The prospect of a widely available severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) vaccine is an increasingly high priority for an effective response to the coronavirus …

Since its peak in early 2016, the incidence of Zika virus (ZIKV) cases has declined to such
low levels that Phase 3 field efficacy trials may be infeasible. While great progress was …

The Covid-19 pandemic creates an unprecedented threatening situation worldwide with an
urgent need for critical reflection and new knowledge production, but also a need for …

While a human challenge study holds the prospect of accelerating the development of a
vaccine for the coronavirus SARS-CoV-2, it may be opposed due to risks of harm to …