When modeling disease in the laboratory, it is important to use clinically relevant models.
Patient-derived human brain cells grown in vitro to study and test potential treatments …

Neurodegenerative disorders are caused by the death and dysfunction of brain cells, but
despite a huge worldwide effort, no neuroprotective treatments that slow cell death currently …

Presynaptic active zones play a pivotal role as synaptic vesicle release sites for synaptic
transmission, but the molecular architecture of active zones in mammalian neuromuscular …

High-content analysis (HCA) combines automated microscopy and automated image
analysis to quantify complex cellular anatomy and biochemistry objectively, accurately and …

Presynaptic active zones are essential structures for synaptic vesicle release, but the
developmental regulation of their number and maintenance during aging at mammalian …

Alzheimer's disease (AD) is a prevalent neurodegenerative disorder manifested by memory
loss, confusion and changes in mood. A principal pathology of this debilitating disorder is …

Microglia and astrocytes play vital roles in normal human brain function and in neurological
disorders. To study their physiological and pathological roles it is desirable to establish in …

Background There is a need for effective computational methods for quantifying the three-
dimensional (3-D) spatial distribution, cellular arbor morphologies, and the morphological …

Microglial cells are the resident immune cells of the central nervous system. Progress in the
recent decade has clearly established that microglial cells participate or even actively drive …

In this article, the authors describe the image analysis software DetecTiff©, which allows fully
automated object recognition and quantification from digital images. The core module of the …