Abstract Purpose of Review The sense of smell is today one of the focuses of interest in
aging and neurodegenerative disease research. In several neurodegenerative diseases …

Decreased olfactory function is very common in the older population, being present in> 50%
of individuals aged between 65 and 80 years and in 62-80% of those> 80 years of age …

Research in animals and humans has associated Alzheimer's disease (AD) with decreased
cerebrospinal fluid levels of insulin in combination with decreased insulin sensitivity (insulin …

Olfactory deficits are present in numerous neurodegenerative disorders and are
accompanied by pathology in related brain regions. In several of these disorders, olfactory …

Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
decline of cognitive function. There is no therapy that can halt or reverse its progression …

The two current major staging systems in use for Lewy body disorders fail to classify up to
50% of subjects. Both systems do not allow for large numbers of subjects who have Lewy …

Smell and taste disorders can markedly affect the quality of life. In recent years we have
become much better in the assessment of the ability to smell and taste. In addition …

Olfactory capacity declines with aging, but increasing evidence shows that smell dysfunction
is one of the early signs of prodromal neurodegenerative diseases such as Alzheimer's and …

Neural stem cells (NSCs) lie at the heart of central nervous system development and repair,
and deficiency or dysregulation of NSCs or their progeny can have significant …

Understanding complex diseases such as sporadic Alzheimer disease (AD) has been a
major challenge. Unlike the familial forms of AD, the genetic and environmental risks factors …