Biomarkers are crucial biological indicators in medical diagnostics and therapy. However,
the process of biomarker discovery and validation is hindered by a lack of standardized …

Contact dermatitis is a common disease that is caused by repeated skin contact with contact
allergens or irritants, resulting in allergic contact dermatitis (ACD) and/or irritant contact …

Drug discovery relies on the knowledge of not only drugs and targets, but also the
comparative agents and targets. These include poor binders and non-binders for developing …

Early diagnosis of Alzheimer's disease plays a pivotal role in patient care and clinical trials.
In this study, we have developed a new approach based on 3D deep convolutional neural …

Allergic diseases and asthma are intrinsically linked to the environment we live in and to
patterns of exposure. The integrated approach to understanding the effects of exposures on …

The network approach is quickly becoming a fundamental building block of computational
methods aiming at elucidating the mechanism of action (MoA) and therapeutic effect of …

With the increasing growth and availability of data, Artificial Intelligence (AI) based black-box
models have shown significant effectiveness to solve real-world and mission-critical …

Abstract Background Cobalt (Co) causes allergic contact dermatitis (ACD) and the emerging
use of Co nanoparticles (CoNPs) warrants gaining further insight into its potential to elicit …

Background Skin exposure to chemicals may induce an inflammatory disease known as
contact dermatitis (CD). Distinguishing the allergic and irritant forms of CD often proves …

The proliferation of omics data has advanced cancer biomarker discovery but often falls
short in external validation, mainly due to a narrow focus on prediction accuracy that …