Dysregulated inflammatory responses play a pivotal role in the initiation, development, and
progression of tumors, as demonstrated by the association between ulcerative colitis and the …

Since its discovery, the STAT3 transcription factor has been extensively studied for its
function as a transcriptional regulator and its role as a mediator of development, normal …

The intestinal epithelium constitutes an indispensable single-layered barrier to protect the
body from invading pathogens, antigens or toxins. At the same time, beneficial nutrients and …

Background Infliximab, a chimeric monoclonal antibody directed against tumor necrosis
factor α, is an established treatment for Crohn's disease but not ulcerative colitis. Methods …

The emergence of novel immunomodulatory cancer therapies over the last decade, above
all immune checkpoint blockade, has significantly advanced tumor treatment. For colorectal …

Background & Aims Tight junction dysregulation and epithelial damage contribute to barrier
loss in patients with inflammatory bowel disease. However, the mechanisms that regulate …

Background & Aims: Toll-like receptors (TLRs) represent a class of transmembrane pattern
recognition receptors essential for microbial recognition and control of innate immune …

Inflammatory bowel disease is characterized by defects in epithelial function and
dysregulated inflammatory signaling by lamina propria mononuclear cells including …

Introduction: Tumor necrosis factor (TNF) receptor 2 (TNFR2) is one of two receptors of the
cytokines, TNF and lymphotoxin-α. TNFR1 is a strong inducer of proinflammatory activities …

Gut microbial metabolites of polyunsaturated fatty acids have attracted much attention
because of their various physiological properties. Dysfunction of tight junction (TJ) in the …