Physiological processes such as the sleep-wake cycle, metabolism and hormone secretion
are controlled by a circadian rhythm adapted to 24 h day-night periodicity. This circadian …

The last decade has seen tremendous progress in our understanding of the organization
and function of the circadian clock. A number of so‐called clock genes were discovered, and …

Circadian rhythms of cell and organismal physiology are controlled by an autoregulatory
transcription-translation feedback loop that regulates the expression of rhythmic genes in a …

First described in the suprachiasmatic nucleus, circadian clocks have since been found in
several peripheral tissues. Although obesity has been associated with dysregulated …

The mammalian circadian clockwork is composed of a core PER/CRY feedback loop and
additional interlocking loops. In particular, the ROR/REV/Bmal1 loop, consisting of ROR …

Most living organisms show circadian (∼ 24 h) rhythms in physiology and behavior. These
oscillations are generated by endogenous circadian clocks, present in virtually all cells …

Circadian gene expression is fundamental to the establishment and functions of the
circadian clock, a cell-autonomous and evolutionary-conserved timing system. Yet, how it is …

Almost all organisms on earth exhibit diurnal rhythms in physiology and behavior under the
control of autonomous time-measuring system called circadian clock. The circadian clock is …

Systems biology is a natural extension of molecular biology; it can be defined as biology
after identification of key gene (s). Systems-biological research is a multistage process …

There is a growing recognition that the circadian timing system, in particular recently
discovered clock genes, plays a major role in a wide range of physiological systems …