▪ Abstract Recent results from ancestral (minimally derived) protists testify to the tremendous
diversity of the mitochondrial genome in various eukaryotic lineages, but also reinforce the …

Although the involvement of genomic factors in bipolar disorder is evident, there are still
many unclear points about its pathophysiology. We proposed the mitochondrial dysfunction …

Abstract The Human Gene Mutation Database (HGMD) constitutes a comprehensive core
collection of data on germ‐line mutations in nuclear genes underlying or associated with …

Progressive damage to mitochondrial DNA (mtDNA) during life is thought to contribute to
aging processes. However, this idea has been difficult to reconcile with the small fraction of …

Abstract MITOMAP (http://www. MITOMAP. org), a database for the human mitochondrial
genome, has grown rapidly in data content over the past several years as interest in the role …

We report here the characterization of a large Chinese family with maternally transmitted
aminoglycoside-induced and nonsyndromic deafness. In the absence of aminoglycosides …

Mutations of mitochondrial (mt) DNA accumulate during normal aging. The most frequent
mutation is a 4,977-base pair deletion also called the common deletion, which is increased …

Background The mitochondrial myopathies typically affect many organ systems and are
associated with mutations in mitochondrial DNA (mtDNA) that are maternally inherited …

A number of mitochondrial (mt) tRNAs have strong structural deviations from the classical
tRNA cloverleaf secondary structure and from the conventional L-shaped tertiary structure …

The recently discovered aging-dependent large accumulation of point mutations in the
human fibroblast mtDNA control region raised the question of their occurrence in postmitotic …