The proto-oncogene ROS1 encodes a receptor tyrosine kinase with an unknown
physiological role in humans. Somatic chromosomal fusions involving ROS1 produce …

DNA methylation of cytosines in CpG sites throughout the genome is an epigenetic mark
contributing to gene expression regulation. DNA methylation patterns are specific to tissue …

IDH-wildtype glioblastoma is a relatively common malignant brain tumor in adults. These
patients generally have dismal prognoses, although outliers with long survival have been …

Gliomas harboring oncogenic ROS1 alterations are uncommon and primarily described in
infants. Our goal was to characterize the clinicopathological features and molecular …

1 3 additional specific oncogenic drivers that not only provide insight into disease
pathogenesis, but also offer targets for personalized cancer therapies. The ROS proto …

High-grade gliomas (HGG) represent about 15% of all pediatric brain tumors, with a dismal
prognosis and survival rates ranging from 15 to 35%. Approximately 10–12% of pediatric …

Simple Summary Central Nervous System (CNS) pediatric tumors represent the most
common solid tumors in children with a wide variability in terms of survival and therapeutic …

Background Central nervous system (CNS) cancer is the 10th leading cause of cancer-
associated deaths for adults, but the leading cause in pediatric patients and young adults …

Background The proto‐oncogene ROS1 encodes an intrinsic type I membrane protein of the
tyrosine kinase/insulin receptor family. ROS1 facilitates the progression of various …

Background Although cervical cancer is often characterized as preventable, its incidence
continues to increase in low‐and middle‐income countries, underscoring the need to …