Traditional approaches to clinical risk assessment utilize age as a marker of increased
vulnerability to stress. Relatively recent advancements in the study of aging have led to the …

Lung endothelia in the arteries, capillaries, and veins are heterogeneous in structure and
function. Lung capillaries in particular represent a unique vascular niche, with a thin yet …

Importance Low diaphragm muscle mass at the outset of mechanical ventilation may
predispose critically ill patients to poor clinical outcomes. Objective To determine whether …

Rationale: The biological mechanisms of long-term cognitive impairment and disability after
critical illness are unclear. Objectives: To test the hypothesis that markers of acute …

Clinical and molecular heterogeneity are common features of human disease.
Understanding the basis for heterogeneity has led to major advances in therapy for many …

Recent work demonstrates increasing trends of geriatric syndromes in the ICU, all of which
are known to confer increased vulnerability among critically ill older adults and decrease the …

Background Patients who survive critical illness suffer from a significant physical disability.
The impact of rehabilitation strategies on health-related quality of life is inconsistent, with …

Pneumonia causes short‐and long‐term cognitive dysfunction in a high proportion of
patients, although the mechanism (s) responsible for this effect are unknown. Here, we …

Numerous studies have identified an association between age-related cognitive impairment
(CI) and oxidative damage, accumulation of metals, amyloid levels, tau, and deranged lipid …

Introduction The frailty present at hospital admission and the stressors to which patients are
subjected during their stay may increase dependency at hospital discharge. Objectives To …