MicroRNA-based diagnosis and therapy

PTB Ho, IM Clark, LTT Le - International journal of molecular sciences, 2022 - mdpi.com
MicroRNAs (miRNAs) are a group of endogenous non-coding RNAs that regulate gene
expression. Alteration in miRNA expression results in changes in the profile of genes …

Progress and prospects of early detection in lung cancer

S Blandin Knight, PA Crosbie, H Balata… - Open …, 2017 - royalsocietypublishing.org
Lung cancer is the leading cause of cancer-related death in the world. It is broadly divided
into small cell (SCLC, approx. 15% cases) and non-small cell lung cancer (NSCLC, approx …

Evaluation of tumor-derived exosomal miRNA as potential diagnostic biomarkers for early-stage non–small cell lung cancer using next-generation sequencing

X Jin, Y Chen, H Chen, S Fei, D Chen, X Cai, L Liu… - Clinical cancer …, 2017 - AACR
Purpose: To identify tumor-derived exosomal biomarkers that are able to discriminate
between adenocarcinoma and squamous cell carcinoma (SCC) as a noninvasive method in …

miRNAs in lung cancer. A systematic review identifies predictive and prognostic miRNA candidates for precision medicine in lung cancer

S Zhong, H Golpon, P Zardo, J Borlak - Translational Research, 2021 - Elsevier
Lung cancer (LC) is the leading cause of cancer-related death worldwide and miRNAs play
a key role in LC development. To better diagnose LC and to predict drug treatment …

Exploring miRNA based approaches in cancer diagnostics and therapeutics

S Mishra, T Yadav, V Rani - Critical reviews in oncology/hematology, 2016 - Elsevier
MicroRNAs (miRNAs), a highly conserved class of tissue specific, small non-protein coding
RNAs maintain cell homeostasis by negative gene regulation. Proper controlling of miRNA …

Methodological challenges in utilizing mi RNA s as circulating biomarkers

L Moldovan, KE Batte, J Trgovcich… - Journal of cellular …, 2014 - Wiley Online Library
Micro RNA s (mi RNA s) have emerged as important regulators in the post‐transcriptional
control of gene expression. The discovery of their presence not only in tissues but also in …

[HTML][HTML] microRNAs derived from circulating exosomes as noninvasive biomarkers for screening and diagnosing lung cancer

R Cazzoli, F Buttitta, M Di Nicola, S Malatesta… - Journal of thoracic …, 2013 - Elsevier
Introduction: Lung cancer is the highest cause of mortality among tumor pathologies
worldwide. There are no validated techniques for an early detection of pulmonary cancer …

MicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer

M Boeri, C Verri, D Conte, L Roz… - Proceedings of the …, 2011 - National Acad Sciences
The efficacy of computed tomography (CT) screening for early lung cancer detection in
heavy smokers is currently being tested by a number of randomized trials. Critical issues …

Circulating miRNAs: roles in cancer diagnosis, prognosis and therapy

G Cheng - Advanced drug delivery reviews, 2015 - Elsevier
MicroRNAs (miRNAs) belong to a class of small non-coding RNAs that regulate numerous
biological processes by targeting a broad set of messenger RNAs. Recently, miRNAs have …

The compact integration of a cascaded HCR circuit for highly reliable cancer cell discrimination

P Dong, R Li, S He, Q Zhang, J Shang, Y Jiang… - Chemical …, 2023 - pubs.rsc.org
The accurate identification of multiple biomarkers involved in disease plays a vital role in
effectively distinguishing cancer cells from normal cells, facilitating reliable cancer …