Humoral immunity depends on the germinal centre (GC) reaction during which somatically
mutated high-affinity memory B cells and plasma cells are generated. Recent studies have …

Germinal centres (GCs) are involved in the selection of B cells secreting high-affinity
antibodies and are also the origin of most human B cell lymphomas. Recent progress has …

Age‐associated B cells (ABCs) have emerged as critical components of immune responses.
Their inappropriate expansion and differentiation have increasingly been linked to the …

The B cell lymphoma 6 (BCL6) transcriptional repressor is a master regulator of the germinal
center (GC) B cell program, required for their unique proliferative and stress tolerant …

The early life influenza disease burden calls for more effective vaccines to protect this
vulnerable population. Influenza vaccines including the MF59 oil-in-water adjuvant induce …

Activation-induced cytidine deaminase (AID) is expressed in a B cell differentiation stage-
specific fashion and is essential for immunoglobulin (Ig) gene class switch DNA …

B cell lymphomas comprise a heterogeneous group of genetically, biologically, and clinically
distinct neoplasms that, in most cases, originate from the clonal expansion of B cells in the …

Purpose MiR-155 is a member of the microRNAs (miRNAs) family and regulates gene
expression post-transcriptionally by binding to the 3'UTR of target mRNA. MiR-155 has a …

Follicular lymphoma (FL), the second most common type of non-Hodgkin lymphoma in the
western world, is characterized by the t (14; 18) translocation, which is present in up to 90 …

Antibody‐secreting cells (ASC) are the effectors of protective humoral immunity and the only
cell type that produces antibodies or immunoglobulins in mammals. In addition to their …