Glutamate is the most abundant free amino acid in the brain and is at the crossroad between
multiple metabolic pathways. Considering this, it was a surprise to discover that glutamate …

Over the past few decades, research on Alzheimer's disease (AD) has focused on
pathomechanisms linked to two of the major pathological hallmarks of extracellular …

GLT-1 (EAAT2; slc1a2) is the major glutamate transporter in the brain, and is predominantly
expressed in astrocytes, but at lower levels also in excitatory terminals. We generated a …

l-Glutamate is the predominant excitatory neurotransmitter in the mammalian central
nervous system and plays important roles in a wide variety of brain functions, but it is also a …

The mammalian genome contains four genes encoding GABA transporters (GAT1, slc6a1;
GAT2, slc6a13; GAT3, slc6a11; BGT1, slc6a12) and five glutamate transporter genes …

Neither normal brain function nor the pathological processes involved in neurological
diseases can be adequately understood without knowledge of the release, uptake and …

Reactive astrocytes have been proposed to become incompetent bystanders in epilepsy as
a result of cellular changes rendering them unable to perform important housekeeping …

Altered glutamate transporter expression is a common feature of many neuropsychiatric
conditions, including schizophrenia. Excitatory amino acid transporters (EAATs) are …

The extracellular levels of excitatory amino acids are kept low by the action of the glutamate
transporters. Glutamate/aspartate transporter (GLAST) and glutamate transporter-1 (GLT-1) …

Traumatic brain injury (TBI) is a major risk factor for developing pharmaco-resistant epilepsy.
Although disruptions in brain circuitry are associated with TBI, the precise mechanisms by …