This monograph, written by the pioneers of IVF and reproductive medicine, celebrates the
history, achievements, and medical advancements made over the last 40 years in this …

Ovarian aging is a natural and physiological aging process characterized by loss of quantity
and quality of oocyte or follicular pool. As it is generally accepted that women are born with a …

Mutations create genetic variation for other evolutionary forces to operate on and cause
numerous genetic diseases. Nevertheless, how de novo mutations arise remains poorly …

Mammals' aging is correlated with the accumulation of somatic heteroplasmic mitochondrial
DNA (mtDNA) mutations. Whether and how aging accumulated mtDNA mutations modulate …

Mitochondria are well known as 'the powerhouses of the cell'. Indeed, their major role is
cellular energy production driven by both mitochondrial and nuclear DNA. Such a feature …

Hereditary optic neuropathies are caused by the degeneration of retinal ganglion cells
whose axons form the optic nerves, with a consistent genetic heterogeneity. As part of our …

The decline of oocyte quality has profound impacts on fertilization, implantation, embryonic
development, and the genetic quality of future generations. One factor that is often ignored …

Stress triggers anticipatory physiological responses that promote survival, a phenomenon
termed allostasis. However, the chronic activation of energy-dependent allostatic responses …

Mutations in mitochondrial DNA (mtDNA) contribute to multiple diseases. However, how new
mtDNA mutations arise and accumulate with age remains understudied because of the high …

Until recently it was thought that most humans only harbor one type of mitochondrial DNA
(mtDNA), however, deep sequencing and single-cell analysis has shown the converse–that …