The gut microbiota is now considered as one of the key elements contributing to the
regulation of host health. Virtually all our body sites are colonised by microbes suggesting …

The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …

Metabolism is an essential part of life that provides energy for cell growth. During metabolic
flux, reactive electrophiles are produced that covalently modify macromolecules, leading to …

Highlights•Explores the mechanism of glycation and AGE production.•Describes the
aberrantly activated pathways through AGE-RAGE interaction.•Emphasizes the important of …

Dicarbonyl stress is the abnormal accumulation of dicarbonyl metabolites leading to
increased protein and DNA modification contributing to cell and tissue dysfunction in aging …

Obesity has reached epidemic proportion worldwide and in all ages. Available evidence
points to a multifactorial pathogenesis involving gene predisposition and environmental …

Receptor for advanced glycation end-products (RAGE) is a multiligand binding and single-
pass transmembrane protein taken in diverse chronic inflammatory conditions. RAGE …

Receptor for advanced glycation end products (RAGE) is an immunoglobulin-like receptor
present on cell surface. RAGE binds to an array of structurally diverse ligands, acts as a …

One of the hallmarks of cancer cells is their metabolic reprogramming, which includes the
preference for the use of anaerobic glycolysis to produce energy, even in presence of …

Epidemiological data have demonstrated a significant association between the presence of
type 2 diabetes mellitus (T2DM) and the development of colorectal cancer (CRC). Chronic …