Angiogenesis, the formation of new blood vessels, is a complex and dynamic process
regulated by various pro-and anti-angiogenic molecules, which plays a crucial role in tumor …

Tumors are comprised of both cancer cells and surrounding stromal components. As an
essential part of the tumor microenvironment, the tumor stroma is highly dynamic …

Immune checkpoint inhibitors have revolutionized medical oncology, although currently only
a subset of patients has a response to such treatment. A compelling body of evidence …

Sepsis is a persistent systemic inflammatory condition involving multiple organ failures
resulting from a dysregulated immune response to infection, and one of the hallmarks of …

Tumor development and metastasis are facilitated by the complex interactions between
cancer cells and their microenvironment, which comprises stromal cells and extracellular …

Tumor blood vessels are a key target for cancer therapeutic management. Tumor cells
secrete high levels of pro-angiogenic factors which contribute to the creation of an abnormal …

In 2009, it was postulated that endothelial cells (ECs) would only be able to execute the
orders of growth factors if these cells would accordingly adapt their metabolism. Ten years …

All solid tumours require a vascular supply in order to progress. Although the ability to
induce angiogenesis (new blood vessel growth) has long been regarded as essential to this …

Tumor growth and metastasis rely on tumor vascular network for the adequate supply of
oxygen and nutrients. Tumor angiogenesis relies on a highly complex program of growth …

Lipid metabolism, in particular the synthesis of fatty acids (FAs), is an essential cellular
process that converts nutrients into metabolic intermediates for membrane biosynthesis …