Biology of Acinetobacter baumannii: Pathogenesis, Antibiotic Resistance Mechanisms, and Prospective Treatment Options

CR Lee, JH Lee, M Park, KS Park, IK Bae… - Frontiers in cellular …, 2017 - frontiersin.org
Acinetobacter baumannii is undoubtedly one of the most successful pathogens responsible
for hospital-acquired nosocomial infections in the modern healthcare system. Due to the …

Trends, epidemiology, and management of multi-drug resistant gram-negative bacterial infections in the hospitalized setting

S Morris, E Cerceo - Antibiotics, 2020 - mdpi.com
The increasing prevalence of antibiotic resistance is a threat to human health, particularly
within vulnerable populations in the hospital and acute care settings. This leads to …

Dissecting colistin resistance mechanisms in extensively drug-resistant Acinetobacter baumannii clinical isolates

V Trebosc, S Gartenmann, M Tötzl, V Lucchini… - MBio, 2019 - Am Soc Microbiol
Nosocomial infections with Acinetobacter baumannii are a global problem in intensive care
units with high mortality rates. Increasing resistance to first-and second-line antibiotics has …

Alternative evolutionary paths to bacterial antibiotic resistance cause distinct collateral effects

C Barbosa, V Trebosc, C Kemmer… - Molecular biology …, 2017 - academic.oup.com
When bacteria evolve resistance against a particular antibiotic, they may simultaneously
gain increased sensitivity against a second one. Such collateral sensitivity may be exploited …

Phage therapy: what have we learned?

A Górski, R Międzybrodzki, M Łobocka… - Viruses, 2018 - mdpi.com
In this article we explain how current events in the field of phage therapy may positively
influence its future development. We discuss the shift in position of the authorities …

Acinetobacter baumannii: Pathogenesis, virulence factors, novel therapeutic options and mechanisms of resistance to antimicrobial agents with emphasis on …

R Dehbanipour, Z Ghalavand - Journal of Clinical Pharmacy …, 2022 - Wiley Online Library
What is known and objective Acinetobacter baumannii is one of the most important
nosocomial pathogens with the ability to cause infections such as meningitis, pneumonia …

Evolutionary stability of collateral sensitivity to antibiotics in the model pathogen Pseudomonas aeruginosa

C Barbosa, R Römhild, P Rosenstiel, H Schulenburg - Elife, 2019 - elifesciences.org
Evolution is at the core of the impending antibiotic crisis. Sustainable therapy must thus
account for the adaptive potential of pathogens. One option is to exploit evolutionary trade …

A nutrient-limited screen unmasks rifabutin hyperactivity for extensively drug-resistant Acinetobacter baumannii

B Luna, V Trebosc, B Lee, M Bakowski, A Ulhaq… - Nature …, 2020 - nature.com
Industry screens of large chemical libraries have traditionally relied on rich media to ensure
rapid bacterial growth in high-throughput testing. We used eukaryotic, nutrient-limited growth …

The tRNA methyltransferase TrmB is critical for Acinetobacter baumannii stress responses and pulmonary infection

JC McGuffey, CD Jackson-Litteken, G Di Venanzio… - Mbio, 2023 - Am Soc Microbiol
Successful pathogens must be able to adapt to a multitude of stressors imposed by their
host. Acinetobacter baumannii has emerged as a major global health threat due to its …

Quantitative contribution of efflux to multi-drug resistance of clinical Escherichia coli and Pseudomonas aeruginosa strains

O Cunrath, DM Meinel, P Maturana, J Fanous… - …, 2019 - thelancet.com
Background Efflux pumps mediate antimicrobial resistance in several WHO critical priority
bacterial pathogens. However, most available data come from laboratory strains. The …