Astroglial Cells: Emerging Therapeutic Targets in the Management of Traumatic Brain Injury

W Czyżewski, M Mazurek, L Sakwa, M Szymoniuk… - Cells, 2024 - mdpi.com
Traumatic Brain Injury (TBI) represents a significant health concern, necessitating advanced
therapeutic interventions. This detailed review explores the critical roles of astrocytes, key …

Role of regulatory non-coding RNAs in traumatic brain injury

S Li, N Qiu, A Ni, MH Hamblin, KJ Yin - Neurochemistry international, 2023 - Elsevier
Traumatic brain injury (TBI) is a potentially fatal health event that cannot be predicted in
advance. After TBI occurs, it can have enduring consequences within both familial and …

YTHDF1 attenuates TBI-induced brain-gut axis dysfunction in mice

P Huang, M Liu, J Zhang, X Zhong… - International Journal of …, 2023 - mdpi.com
The brain-gut axis (BGA) is a significant bidirectional communication pathway between the
brain and gut. Traumatic brain injury (TBI) induced neurotoxicity and neuroinflammation can …

Enhancing daily living and cognitive functions in traumatic brain injury patients through Orem's self-care theory

P Sha, X Gao, R Yu, Y Li, Y Zhang, Z Zhu, T Wu… - Frontiers in …, 2024 - frontiersin.org
Introduction This research seeks to investigate how early rehabilitation nursing, guided by
Orem's self-care theory, affects cognitive function, neurological function, and daily living …

Dual roles of microglia in the pathological injury and repair of hemorrhagic cerebrovascular diseases

L Tan, J Liang, X Wang, Y Wang… - Regenerative Medicine …, 2024 - journals.lww.com
Microglia are one of the most important immune cells in the central nervous system, which
mainly play an immune surveillance role under normal conditions to maintain central …

Dynamics of synaptic damage in severe traumatic brain injury revealed by cerebrospinal fluid SNAP-25 and VILIP-1

F olde Heuvel, Z Li, D Riedel… - Journal of Neurology …, 2024 - jnnp.bmj.com
Background Biomarkers of neuronal, glial cells and inflammation in traumatic brain injury
(TBI) are available but they do not specifically reflect the damage to synapses, which …

The FGFR inhibitor Rogaratinib reduces microglia reactivity and synaptic loss in TBI

R Rehman, A Froehlich, F olde Heuvel, L Elsayed… - bioRxiv, 2024 - biorxiv.org
Background: Traumatic brain injury (TBI) induces an acute reactive state of microglia, which
contribute to secondary injury processes through phagocytic activity and release of …

Transkriptom nach Schädel-Hirn-Trauma: Effekte einer Inhibition der NF-κB-regulierten Neuroinflammation in Astrozyten

H Wendt - 2024 - oparu.uni-ulm.de
Der genaue Ablauf und die Abfolge der molekularen Prozesse nach einem Schädel-Hirn-
Trauma (SHT) sind von großem Interesse für die Entwicklung neuer therapeutischer …