Mechanisms of manganese-induced neurotoxicity and the pursuit of neurotherapeutic strategies

E Pajarillo, I Nyarko-Danquah, A Digman… - Frontiers in …, 2022 - frontiersin.org
Chronic exposure to elevated levels of manganese via occupational or environmental
settings causes a neurological disorder known as manganism, resembling the symptoms of …

[HTML][HTML] Medicinal applications of d-ribose l-cysteine in neuro-endocrinopathy, reproductive dysfunction and cardio-metabolic syndrome: A review of evidence in …

OM Obukohwo, FY Faith, OE Peggy… - European Journal of …, 2024 - Elsevier
In recent years, the emergence of d-ribose l-cysteine (DLRC) as a potential treatment
regimen for neuro-endocrinopathy, reproductive dysfunction and cardio-metabolic syndrome …

Microglia signaling pathway reporters unveiled manganese activation of the interferon/STAT1 pathway and its mitigation by flavonoids

VV Mossine, JK Waters, GY Sun, Z Gu… - Molecular …, 2023 - Springer
Neuroinflammatory responses to neurotoxic manganese (Mn) in CNS have been associated
with the Mn-induced Parkinson-like syndromes. However, the framework of molecular …

[HTML][HTML] Synergistic suppression of BDNF via epigenetic mechanism deteriorating learning and memory impairment caused by Mn and Pb co-exposure

L Wei, H He, S Yang, Q Shi, X Wang, L Huang… - Ecotoxicology and …, 2024 - Elsevier
Abstracts Microglia, the resident immune cells of the central nervous system (CNS), play a
dual role in neurotoxicity by releasing the NLR Family Pyrin Domain Containing 3 (NLRP3) …

[HTML][HTML] Mechanism of KAT2A regulation of H3K36ac in manganese-induced oxidative damage to mitochondria in the nervous system and intervention by curcumin

Y Liu, JM Zeng, H Zhao, CY Ao, LH Ao, JQ Ban… - … and Environmental Safety, 2024 - Elsevier
Excessive exposure to manganese in the environment or workplace is strongly linked to
neurodegeneration and cognitive impairment, but the precise pathogenic mechanism and …