Telomeres are dynamic nucleoprotein-DNA structures that cap and protect linear
chromosome ends. Because telomeres shorten progressively with each replication, they …

Chromosomal instability (CIN) is associated with many human diseases, including
neurodevelopmental or neurodegenerative conditions, age-related disorders and cancer …

Telomere integrity is essential for genome stability and it regulates cell proliferation and
tissue renewal. Several lines of evidence indicate that telomeres are particularly sensitive to …

Base excision repair (BER) corrects forms of oxidative, deamination, alkylation, and abasic
single-base damage that appear to have minimal effects on the helix. Since its discovery in …

The NEIL3 DNA glycosylase is a base excision repair enzyme that excises bulky base
lesions from DNA. Although NEIL3 has been shown to unhook interstrand crosslinks (ICL) in …

G-quadruplexes are four-stranded guanine-rich structures that have been demonstrated to
occur across the genome in humans and other organisms. They provide regulatory functions …

Cancer is the second most fatal disease worldwide, with colon cancer being the third most
prevalent and fatal form of cancer in several Western countries. The risk of acquisition of …

The NEIL3 DNA repair gene is induced in cells or animal models experiencing oxidative or
inflammatory stress along with oxidation of guanine (G) to 8-oxo-7, 8-dihydroguanine (OG) …

Cellular senescence caused by oncogenic stimuli is associated with the development of
various age-related pathologies through the senescence-associated secretory phenotype …

Telomeres (TLs) play major roles in stabilizing the genome and are usually shortened with
ageing. The maintenance of TLs is ensured by two mechanisms involving telomerase (TA) …