We examine similar and differential effects of two senolytic treatments, ABT‐263 and
dasatinib+ quercetin (D+ Q), in preserving cognition, markers of peripheral senescence, and …

With increased life expectancy, age-associated cognitive decline becomes a growing
concern, even in the absence of recognizable neurodegenerative disease. The integrated …

Aging is characterized by a progressive loss of brain volume at an estimated rate of 5% per
decade after age 40. While these morphometric changes, especially those affecting gray …

Physical activity is a powerful lifestyle factor capable of improving cognitive function,
modifying the risk for dementia associated with neurodegeneration and possibly slowing …

Modifiable lifestyle factors have been shown to promote healthy brain ageing. However,
studies have typically focused on a single factor at a time. Given that lifestyle factors do not …

There are sex differences in vulnerability and resilience to the stressors of aging and
subsequent age-related cognitive decline. Cellular senescence occurs as a response to …

Independently, obesity and physical activity (PA) influence cerebral structure in aging, yet
their interaction has not been investigated. We examined sex differences in the relationships …

Health benefits of physical activity (PA) are well known; however, specific PA patterns that
relate most strongly to cognitive aging outcomes are poorly understood. We characterized …

Monitoring fatigue and recovery during training periods contributes to identifying the best
training methods to achieve sports performance. To date, little is known about sex-related …

Disrupted brain structures and several life environmental factors have been shown to
influence depression and anxiety, but their interactions with anxiety and depression remain …