Mesangial cells originate from the metanephric mesenchyme and maintain structural
integrity of the glomerular microvascular bed and mesangial matrix homeostasis. In …

Diabetic nephropathy is one of the most prevalent microvascular complication in patients
suffering from diabetes and is reported to be the major cause of renal failure when …

Chronic kidney disease (CKD) is becoming a worldwide epidemic, driven largely by the
dramatic rise in the prevalence of diabetes and obesity. Novel targets and treatments for …

Obesity in combination with diabetes and hypertension likely is contributing to the increasing
incidence of chronic kidney disease (CKD) in the 21st century worldwide and requires novel …

Despite considerable efforts to better characterize the pathophysiology of obesity-related
metabolic disease, there are still a lack of efficient therapeutic strategies. New strategies …

The paradigm that high glucose drives overproduction of superoxide from mitochondria as a
unifying theory to explain end organ damage in diabetes complications has been tightly held …

Increased basic fibroblast growth factor‐2 (FGF2) and reduced Klotho have both been
reported to be closely associated with renal fibrosis. However, the relationship between …

The aim was to explore the effects of rapamycin on autophagy and injury of podocytes in
streptozocin (STZ)-induced type 1 diabetic mice, and its role in delaying progression of …

Glomerular mesangial matrix expansion and cell autophagy are the most important factors in
the development of kidney damage under diabetic conditions. The activation of AMPK might …

Background Diabetic nephropathy (DN) is a chronic microvascular complication in patients
with diabetes mellitus, which is the leading cause of end-stage renal disease. However, the …