Mitochondrial cytochrome c oxidase (COX) is the primary site of cellular oxygen
consumption and is essential for aerobic energy generation in the form of ATP. Human COX …

Respiratory chain dysfunction plays an important role in human disease and aging. It is now
well established that the individual respiratory complexes can be organized into …

The peri-menopause or menopausal transition—the time period that surrounds the final
years of a woman's reproductive life—is associated with profound reproductive and …

Deep understanding of the pathophysiological role of the mitochondrial respiratory chain
(MRC) relies on a well-grounded model explaining how its biogenesis is regulated. The lack …

Mitochondrial ribosomes translate membrane integral core subunits of the oxidative
phosphorylation system encoded by mtDNA. These translation products associate with …

Over the past sixty years, researchers have made outmost efforts to clarify the structural
organization and functional regulation of the complexes that configure the mitochondrial …

Non-alcoholic fatty liver disease (NAFLD) is an increasingly prevalent disease globally.
Current estimates are that 24% of the adult population, thus, one billion individuals …

The biogenesis and function of the mitochondrial respiratory chain (RC) involve the
organization of RC enzyme complexes in supercomplexes or respirasomes through an …

Mitochondrial respiratory-chain complexes assemble from subunits of dual genetic origin
assisted by specialized assembly factors. Whereas core subunits are translated on …

Eukaryotic cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial
respiratory chain. COX is a multimeric enzyme formed by subunits of dual genetic origin …