The past 20 years have seen dramatic changes in the delivery of radiation therapy, but the
impact of radiobiology on the clinic has been far less substantial. A major consideration in …

Oral cavity cancer (OCC) is associated with high incidence of loco-regional recurrences,
which account for the majority of treatment failures post-surgery and radiotherapy. The time …

Activation of Hedgehog (Hh) signaling is implicated in the development and progression of
several tumor types, including prostate cancer, which is still the most common non-skin …

The epidermal growth factor receptor (EGFR) plays an important role in tumor progression
and treatment resistance for many types of malignancies including head and neck …

Purpose To develop a novel approach for increasing radiosensitivity in glioblastoma (GBM)
by using targeted nanoparticles to deliver siRNA aimed at silencing the EGFR and …

Purpose To explore patterns of Notch receptor and ligand expression in response to
radiation that could be crucial in defining optimal dosing schemes for γ-secretase inhibitors if …

Introduction Preoperative chemoradiotherapy represents the standard treatment for patients
with locally advanced rectal cancer. Unfortunately, the response of individual tumors to …

Purpose To assess safety and activity of neoadjuvant bevacizumab, capecitabine and
standard radiotherapy in locally advanced rectal cancer as well as potential predictive …

Translational medical research literatures have increased rapidly in last decades and there
have been fewer attempts or efforts to map global research context of translational medical …

Locally advanced rectal cancer is currently treated with pre-operative radiochemotherapy
(pRCT), but the response is not uniform. Identification of patients with higher likelihood of …