The extracellular matrix (ECM) surrounding cells is indispensable for regulating their
behavior. The dynamics of ECM signaling are tightly controlled throughout growth and …

Introduction Immune-checkpoint inhibitors (ICIs) have emerged as a core pillar of cancer
therapy as single agents or in combination regimens both in adults and children …

Background We aimed to predict response to biologics in inflammatory bowel disease (IBD)
using computerized image analysis of probe confocal laser endomicroscopy (pCLE) in vivo …

Background Colorectal cancer is one of the most frequent and deadly tumors. Among the
key regulators of CRC growth and progression, the microenvironment has emerged as a …

Background Gastric cancer is one of the deadliest cancers, currently available therapies
have limited success. Cancer-associated fibroblasts (CAFs) are pivotal cells in the stroma of …

Animal models for colitis-associated colorectal cancer (CACC) represent an important tool to
explore the mechanistic basis of cancer-related inflammation, providing important evidence …

Okra flowers are a good source of polysaccharides and flavonoids, with biological activities
of anti-inflammatory action and modulation of the gut microbiota. Previously, we reported …

Background The contribution of the tumor microenvironment and extracellular matrix to the
aggressive biology of Gastric Cancer (GC) has been recently characterized; however, the …

Alterations in extracellular matrix (ECM) components that modulate inflammatory cell
behavior have been shown to serve as early starters for multifactorial diseases such as …

Inflammatory bowel diseases (IBDs) constitute a group of chronic intestinal conditions
prominently featuring deranged metabolism. Effective pharmacological treatments for IBDs …