The treatment of advanced thyroid cancer has undergone rapid evolution in the last decade,
with multiple kinase inhibitor drug approvals for each subtype of thyroid cancer and a …

The incidence of melanoma, among the most lethal cancers, is widespread and increasing.
Metastatic melanoma has a poor prognosis, representing about 90% of skin cancer …

Introduction Previous studies have reported an acquiredBRAF V600E mutation as a
potential resistance mechanism to osimertinib treatment in advanced NSCLC patients with …

Image-based analysis as a rapid method for mutation detection can be advantageous in
research or clinical settings when tumor tissue is limited or unavailable for direct testing …

There has been a rapid increase in adjuvant therapies approved for treatment following
surgical resection of stages III/IV melanoma. We review current indications for adjuvant …

Purpose Evaluation of genetic mutations in cancers is important because distinct mutational
profiles help determine individualized drug therapy. However, molecular analyses are not …

Context.—In 2014, the College of American Pathologists developed an evidence-based
guideline to address analytic validation of immunohistochemical assays. Fourteen …

Aims Precision medicine therapy is remodelling the diagnostic landscape of cancer. The
success of these new therapies is often based on the presence or absence of a specific …

Methods The MEDLINE and Google Scholar databases were searched to retrieve studies
addressing the Idylla system performance compared with other diagnostic methods. Only …

The Idylla Mutation Test System is an automated, PCR-based mutation testing system. The
advantages of this system can greatly impact the delivery of precision medicine. We …