Molecular mechanisms and clinical implications of the gold drug auranofin
S Shen, J Shen, Z Luo, F Wang, J Min - Coordination Chemistry Reviews, 2023 - Elsevier
Auranofin (AUR) is an orally available lipophilic gold-based anti-inflammatory compound
used for the treatment of rheumatoid arthritis (RA). Recent evidence indicates that AUR may …
used for the treatment of rheumatoid arthritis (RA). Recent evidence indicates that AUR may …
Molecular dynamics simulation of protein and protein–ligand complexes
R Shukla, T Tripathi - Computer-aided drug design, 2020 - Springer
Biomacromolecules, including proteins and their complexes, adopt multiple conformations
that are linked to their biological functions. Though some of the structural heterogeneity can …
that are linked to their biological functions. Though some of the structural heterogeneity can …
Structural analysis of biomacromolecules using circular dichroism spectroscopy
X Zhao, Y Wang, D Zhao - … Methods to Study Biomolecular Structure and …, 2023 - Elsevier
The chirality of biomacromolecules renders circular dichroism (CD) detection a method to
measure their multiscale structures. This chapter reviews the applications of CD …
measure their multiscale structures. This chapter reviews the applications of CD …
Development of multi-epitope driven subunit vaccine against Fasciola gigantica using immunoinformatics approach
Fascioliasis, a serious helminth disease of the livestock population, results from infection
with the parasite Fasciola. Despite the alarming increase in drug resistance, a safe and fully …
with the parasite Fasciola. Despite the alarming increase in drug resistance, a safe and fully …
Phase separation, aggregation, and complexation of triton-X100 and bovine serum albumin mixture: A combined cloud point and UV–visible spectroscopic …
HA Bhuiyan, JM Khan, D Kumar, MK Banjare… - International Journal of …, 2024 - Elsevier
Phase separation and aggregation behaviour of triton X-100 (TX-100) and bovine serum
albumin (BSA) mixture were investigated using cloud point and UV–visible spectroscopic …
albumin (BSA) mixture were investigated using cloud point and UV–visible spectroscopic …
Autonomous Non Antioxidant Roles for Fasciola hepatica Secreted Thioredoxin-1 and Peroxiredoxin-1
A Dorey, K Cwiklinski, J Rooney… - Frontiers in cellular …, 2021 - frontiersin.org
Trematode parasites of the genus Fasciola are the cause of liver fluke disease (fasciolosis)
in humans and their livestock. Infection of the host involves invasion through the intestinal …
in humans and their livestock. Infection of the host involves invasion through the intestinal …
Thiol antioxidant thioredoxin reductase: A prospective biochemical crossroads between anticancer and antiparasitic treatments of the modern era
N Joardar, A Guevara-Flores… - International Journal of …, 2020 - Elsevier
The thiol-based glutathione reductase (GR) and thioredoxin reductase (TrxR) are the major
antioxidant enzymes present in various organisms that maintain the internal redox …
antioxidant enzymes present in various organisms that maintain the internal redox …
Efficient purification of selenoprotein thioredoxin reductase 1 by using chelating reagents to protect the affinity resins and rescue the enzyme activities
Abstract The application of 2', 5'-ADP Sepharose affinity chromatography is used to purify
the recombinantly expressed selenoprotein thioredoxin reductases (TrxRs, TXNRDs) …
the recombinantly expressed selenoprotein thioredoxin reductases (TrxRs, TXNRDs) …
Descriptive Analysis of Transient-State Observations for Thioredoxin/Glutathione Reductase (Sec597Cys) from Schistosoma mansoni
Thioredoxin/glutathione reductase from Schistosoma mansoni (SmTGR) catalyzes the
reduction of both oxidized thioredoxin and glutathione with electrons from reduced …
reduction of both oxidized thioredoxin and glutathione with electrons from reduced …
Functional expression, localization, and biochemical characterization of thioredoxin glutathione reductase from air-breathing magur catfish, Clarias magur
The glutathione (GSH) and thioredoxin (Trx) systems regulate cellular redox homeostasis
and maintain antioxidant defense in most eukaryotes. We earlier reported the absence of …
and maintain antioxidant defense in most eukaryotes. We earlier reported the absence of …