Autophagy and apoptosis are two important cellular processes with complex and
intersecting protein networks; as such, they have been the subjects of intense investigation …

Lipopolysaccharide (LPS) from Gram-negative bacteria is one of the most potent innate
immune-activating stimuli known. Here we review the current understanding of LPS effects …

Gene therapy, which involves replacement of a defective gene with a functional, healthy
copy of that gene, is a potentially beneficial cancer treatment approach particularly over …

The Growth Arrest and DNA Damage-inducible 45 (GADD45) proteins have been implicated
in regulation of many cellular functions including DNA repair, cell cycle control, senescence …

In 2001, six immune mediators (IL-10, IL-19, IL-20, IL-22, IL-24, and IL-26) were grouped
into the so-called IL-10 family of cytokines based on their similarities with respect to the …

The functional relevance of autophagy in tumor formation and progression remains
controversial. Autophagy can promote tumor suppression during cancer initiation and …

Introduction: Human cancers are genetically and epigenetically heterogeneous and have
the capacity to commandeer a variety of cellular processes to aid in their survival, growth …

The continuous rise in skin cancer incidence highlights an imperative for improved skin
cancer prevention. Topical calcipotriol-plus–5-fluorouracil (calcipotriol-plus–5-FU) …

First identified almost two decades ago as a novel gene differentially expressed in human
melanoma cells induced to terminally differentiate, MDA-7/IL-24 has since shown great …

Oncolytic adenovirus (OncoAd) is a promising therapeutic agent for treating cancer.
However, the therapeutic potential of OncoAd is hindered by hepatic sequestration and the …