Tremendous chemical diversity is the hallmark of plants and is supported by highly complex
biochemical machinery. Plant metabolic enzymes originated and were transferred from …

Human Vγ2Vδ2 T cells play important roles in mediating immunity against microbial
pathogens and have potent anti‐tumor activity. Vγ2Vδ2 T cells recognize the …

The human intestinal microbiota is composed of 1013 to 1014 microorganisms whose
collective genome (“microbiome”) contains at least 100 times as many genes as our own …

Epithelial and mucosal barriers are critical interfaces physically separating the body from the
outside environment and are the tissues most exposed to microorganisms and potential …

While most T cells use a CD3-associated α/β T cell receptor as antigen recognition structure,
a second population of T cells expresses the alternative γ/δ T cell receptor. γ/δ T cells are a …

The study of T cell memory and the target of vaccine design have focused on memory
subsumed by T cells bearing the αβ T cell receptor. Alternatively, γδ T cells are thought to …

Isoprenoid biosynthesis is essential for cell survival. Over 35 000 isoprenoid molecules have
been identified to date in the three domains of life (bacteria, archaea and eukaryotes), and …

The development of vaccines against Staphylococcus aureus has consistently failed in
clinical trials, likely due to inefficient induction of cellular immunity. T cell–derived IL-17 is …

Vγ9Vδ2 T cells, a major human peripheral γδ T-cell subset, react in vitro against a wide
array of microbial agents and tumor cells. This broad reactivity pattern is conferred by non …

Isoprenoids and their derivatives represent the largest group of organic compounds in
nature and are distributed universally in the three domains of life. Isoprenoids are …