The role of the adaptive immune system and T cell dysfunction in neurodegenerative diseases

A DeMaio, S Mehrotra, K Sambamurti… - Journal of …, 2022 - Springer
The adaptive immune system and associated inflammation are vital in surveillance and host
protection against internal and external threats, but can secondarily damage host tissues …

The pathophysiology and treatment of glaucoma: a review

RN Weinreb, T Aung, FA Medeiros - Jama, 2014 - jamanetwork.com
Importance Glaucoma is a worldwide leading cause of irreversible vision loss. Because it
may be asymptomatic until a relatively late stage, diagnosis is frequently delayed. A general …

The molecular basis of retinal ganglion cell death in glaucoma

M Almasieh, AM Wilson, B Morquette… - Progress in retinal and …, 2012 - Elsevier
Glaucoma is a group of diseases characterized by progressive optic nerve degeneration that
results in visual field loss and irreversible blindness. A crucial element in the …

Primary open-angle glaucoma

RN Weinreb, PT Khaw - The lancet, 2004 - thelancet.com
Primary open-angle glaucoma is a progressive optic neuropathy and, perhaps, the most
common form of glaucoma. Because the disease is treatable, and because the visual …

Primary open-angle glaucoma

YH Kwon, JH Fingert, MH Kuehn… - New England Journal …, 2009 - Mass Medical Soc
Primary Open-Angle Glaucoma | New England Journal of Medicine Skip to main content The
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …

[HTML][HTML] Extension of retinofugal projections in an assembled model of human pluripotent stem cell-derived organoids

CM Fligor, SS Lavekar, J Harkin, PK Shields… - Stem Cell Reports, 2021 - cell.com
The development of the visual system involves the coordination of spatial and temporal
events to specify the organization of varied cell types, including the elongation of axons from …

Paracrine-mediated neuroprotection and neuritogenesis of axotomised retinal ganglion cells by human dental pulp stem cells: comparison with human bone marrow …

B Mead, A Logan, M Berry, W Leadbeater… - PloS one, 2014 - journals.plos.org
We have investigated and compared the neurotrophic activity of human dental pulp stem
cells (hDPSC), human bone marrow-derived mesenchymal stem cells (hBMSC) and human …

A biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucoma

CF Burgoyne - Experimental eye research, 2011 - Elsevier
This article is dedicated to Rosario Hernandez for her warm support of my own work and her
genuine enthusiasm for the work of her colleagues throughout her career. I first met Rosario …

Critical pathogenic events underlying progression of neurodegeneration in glaucoma

DJ Calkins - Progress in retinal and eye research, 2012 - Elsevier
Glaucoma is a common optic neuropathy with a complex etiology often linked to sensitivity to
intraocular pressure. Though the precise mechanisms that mediate or transduce this …

Current concepts in the diagnosis, pathogenesis and management of nonarteritic anterior ischaemic optic neuropathy

NR Miller, AC Arnold - Eye, 2015 - nature.com
Nonarteritic anterior ischaemic optic neuropathy (NAION) is the most common acute optic
neuropathy in patients over the age of 50 and is the second most common cause of …